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Please be aware of the following important safety information regarding the use of this medication. It is crucial to understand the potential risks and necessary precautions. Consult your healthcare provider if you have any questions or concerns.

• Smoking and Cardiovascular Risks: If you are a smoker and over the age of 35, using hormonal birth control like Natazia can significantly increase your risk of serious cardiovascular events, including strokes, heart attacks, and blood clots. The risk escalates with age and the number of cigarettes smoked. Smoking cessation is strongly advised.

• Blood Clots and Strokes: Natazia can heighten the risk of blood clots in various parts of the body, such as the lungs, legs, brain, and heart. Seek immediate medical help if you notice signs of a blood clot. This risk is greater for women over 35 who smoke, individuals with recent surgeries, those with high blood pressure, obesity, high cholesterol, diabetes, or a history of certain conditions.

• Cancer Risks: There is a potential, albeit mixed, risk of breast and cervical cancer from long-term use of Natazia. Discuss with your doctor if you have a history of breast cancer.

• Liver Concerns: Rarely, Natazia may cause liver damage or tumors. Contact your healthcare provider if you experience symptoms like fatigue, abdominal pain, or jaundice, especially if you have a history of liver problems.

• Hypertension: This medication can raise blood pressure. Regular monitoring is recommended, and it may not be suitable for individuals with uncontrolled hypertension.

• Blood Sugar and Lipid Levels: Natazia may increase blood sugar and triglyceride levels. If you have diabetes or a history of high triglycerides, monitor your health closely and report any changes to your healthcare provider.

• Headaches and Depression: Common side effects include headaches; however, severe or atypical headaches should be evaluated. Additionally, if you experience new or worsening depression, inform your healthcare provider promptly.

• Irregular Bleeding: Spotting and irregular bleeding can occur, especially during the initial months of use. Report any unusual bleeding patterns to your healthcare professional.

• Drug Interactions: Certain medications can reduce the effectiveness of Natazia. Inform your healthcare provider of all medications you are taking to avoid potential interactions.

• Worsening of Other Conditions: If you have hereditary angioedema or a history of chloasma, discuss the potential for symptom exacerbation with your healthcare provider. Avoid sun exposure if you have a history of chloasma.

In cases of overdose, seek emergency medical assistance immediately. Natazia is contraindicated for individuals with certain health conditions, including smoking over the age of 35, history of blood clots, certain heart diseases, uncontrolled hypertension, severe diabetes complications, undiagnosed abnormal bleeding, certain types of headaches, history of breast cancer, and liver disease or tumors. Always discuss your medical history with your healthcare provider before starting this medication.

When taking this medication, some individuals may experience common side effects such as headaches, breast tenderness, irregular vaginal bleeding, nausea, vomiting, and acne. These symptoms are generally mild, but if they persist or worsen, consulting a healthcare provider is advised. Mood changes and weight gain are also possible, though they occur less frequently.

Other side effects that may occur include abdominal pain, dizziness, fluid retention, rash, and vaginal yeast infections. Again, while these are typically mild, seeking medical advice is recommended if they become bothersome.

More serious side effects, though rare, require immediate medical attention. These include signs of a heart attack such as chest pain, nausea, and dizziness; symptoms of a stroke like sudden numbness or difficulty speaking; deep vein thrombosis marked by leg pain and swelling; and pulmonary embolism indicated by trouble breathing and chest pain. Serious liver issues may manifest as yellowing of the skin or eyes and extreme tiredness. Additionally, a ruptured ovarian cyst may cause severe abdominal pain, nausea, and unusual vaginal bleeding.

While a severe allergic reaction to this medication is uncommon, symptoms such as a rash, itching, severe dizziness, or difficulty breathing should prompt urgent medical attention. Always consult your healthcare provider if you notice any unusual effects not listed above.