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You might experience some mild side effects from this medication, such as drowsiness, dizziness, headache, blurred vision, upset stomach, nausea, constipation, or dryness in your mouth, nose, or throat. These are common and usually manageable. For dry mouth, try using sugarless candy or gum, drinking water, or trying a saliva substitute. To prevent dizziness or lightheadedness, rise slowly from sitting or lying down.

However, this medication can cause mucus in your lungs to thicken, making breathing more difficult. Drinking plenty of fluids can help mitigate this effect. Although most people do not experience severe side effects, it's important to be aware of them. Contact your healthcare provider immediately if you experience mental or mood changes, ringing in the ears, shaking, trouble urinating, weakness, unusual bruising or bleeding, or irregular heartbeat. Seizures are also a serious concern.

Although rare, a serious allergic reaction may occur. Seek immediate medical attention if you notice symptoms like a rash, severe dizziness, or difficulty breathing, especially if there is swelling of the face, tongue, or throat. If you experience any other unusual effects, consult your healthcare professional for guidance.

Certain MAO inhibitors can lead to a severe and potentially life-threatening interaction with this medication. You should not take isocarboxazid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while using this medication. Additionally, it is usually recommended to avoid most MAO inhibitors for two weeks before and after stopping this medication. Consult your doctor for guidance on when to begin or discontinue use.

Other substances that may interact with this drug include topical antihistamines (like diphenhydramine cream, ointment, or spray) and rolapitant. Inform your doctor or pharmacist if you are using other products that can cause drowsiness, such as opioid painkillers or cough suppressants (e.g., codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or other antihistamines (e.g., Cetirizine, diphenhydramine).

Be sure to check the labels on all your medications, including those for allergies or cold symptoms, as they may contain ingredients that cause drowsiness. Your pharmacist can advise you on safe usage. This medication might interfere with certain medical or laboratory tests, such as brain scans for Parkinson's disease, urine drug screenings, or allergy skin tests, potentially leading to incorrect results. Ensure that all lab personnel and your healthcare providers know you are taking this medication.