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The following information outlines important safety considerations and warnings associated with the use of this medication. Please read them carefully and consult your healthcare professional if you have any questions or concerns.

• Medication Interactions: Inform your healthcare provider or pharmacist about all the medications and supplements you are taking before starting norethindrone. This will allow them to check for any potential interactions.

• Ectopic Pregnancy or Ovarian Cyst: In the event you become pregnant while taking norethindrone, there is a small risk that the pregnancy could be ectopic, meaning it occurs outside the womb. This condition is serious and requires immediate medical attention. Seek help if you experience symptoms such as cramping or pain in the lower abdomen or shoulder area.

• Irregular Vaginal Bleeding: Experiencing irregular vaginal bleeding is a common side effect of progestin-only pills (POPs) like norethindrone. Although rare, it might indicate a more serious condition, such as an infection or cancer. Consult your healthcare provider if you are concerned about irregular bleeding. Additionally, if you experience an absence of bleeding, it is advisable to check with your provider to confirm whether you might be pregnant.

• Possible Risk of Cancer: Some research has suggested that combination birth control pills may increase the risk of breast or ovarian cancer. However, it is unclear if norethindrone or other POPs carry the same risk. Discuss any concerns about cancer risk with your healthcare provider.

Contraindications: This medication should not be used under the following conditions, as it may present serious health risks. Consult with your healthcare provider if any of the following apply:

• Pregnancy
• Confirmed or suspected breast cancer
• Unexplained bleeding between menstrual periods
• Liver tumors, whether benign or cancerous
• Sudden onset of liver disease

This information is crucial for ensuring the safe use of the medication, and following these guidelines can help prevent adverse effects.

When taking this medication, you may experience some common side effects such as nausea, vomiting, headaches, bloating, breast tenderness, or weight gain. It's not unusual to notice vaginal bleeding between periods, spotting, or even missed or irregular periods. These effects are generally mild and often resolve on their own. However, if they persist or worsen, it’s important to reach out to your healthcare provider for advice.

In some cases, more serious side effects can occur. Be vigilant for any lumps in the breast, significant mental or mood changes such as new or worsening depression, severe stomach or abdominal pain, or unusual changes in vaginal bleeding. Also, be aware of signs like dark urine or yellowing of the eyes and skin, which may indicate liver issues. If any of these symptoms arise, contact your healthcare provider immediately as they may require urgent attention.

Although rare, severe allergic reactions can happen. Seek emergency medical help if you experience symptoms such as a rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, or difficulty breathing. Remember, while serious side effects are uncommon, staying informed and prepared is crucial for your health and safety.