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This safety and warning guide provides crucial information regarding the potential risks associated with the use of somatropin injections such as Omnitrope. Please read carefully and consult your healthcare provider if you have any concerns.

• Increased Mortality Risk: Avoid somatropin injections in individuals with short-term critical illnesses like those recovering from open heart or abdominal surgeries, serious injuries, or severe respiratory issues. Using the medication in these cases may heighten the risk of death.

• Prader-Willi Syndrome Concerns: Children with Prader-Willi syndrome who are obese, have airway blockages, or undiagnosed respiratory infections are at risk of sudden death when using somatropin. Children without these risk factors may use the medication under strict medical supervision, ensuring weight control and monitoring for respiratory symptoms. Discontinue use and contact a provider if breathing issues or increased snoring occur.

• Severe Allergic Reactions: Users may experience life-threatening allergic responses, including anaphylaxis. Symptoms like dizziness, throat constriction, breathing difficulties, nausea, and swelling around the eyes, lips, or tongue require immediate medical attention.

• Cancer Risks: Do not use if you or your child has an active tumor or history of cancer, as somatropin may increase cancer risks. Consult your provider if you notice behavioral changes, headaches, vision problems, or skin color changes.

• Diabetes Risk: Somatropin may elevate blood sugar levels, increasing diabetes risk, especially in those with obesity, Turner syndrome, or a family history of diabetes. Regular blood sugar monitoring is advised, and diabetes medication dosages may need adjusting.

• Intracranial Hypertension: Some users may experience increased brain pressure, leading to symptoms like vision changes, headaches, nausea, and vomiting, which typically arise within eight weeks of starting treatment. Discontinue use and seek medical advice if symptoms persist.

• Fluid Retention: Somatropin can cause fluid retention, resulting in swelling in limbs, muscle pain, or carpal tunnel syndrome. Inform your provider if these symptoms occur; they may resolve independently or require dosage adjustment.

• Low Cortisol Levels: Somatropin may lower cortisol levels, particularly in those taking steroid hormones like prednisone. This effect may impact stress and inflammation regulation.

• Bone Issues in Children: Rapidly growing children may experience a condition where the thigh bone slips out of place, causing knee or hip pain and limping. Notify your provider if these symptoms arise.

• Pancreatitis: Rarely, somatropin may cause pancreatitis, manifested by severe stomach pain, nausea, and vomiting. Cease use and seek immediate medical assistance if these occur.

Contraindications: Do not use somatropin in the following cases:

• Short-term critical illness from surgeries, serious injuries, or severe respiratory issues.
• Active cancer or severe diabetic eye damage.
• Severely obese children with Prader-Willi syndrome or those with serious breathing issues or sleep apnea.
• Children who have ceased growth (closed epiphyses).

For any concerns or queries, always consult your healthcare provider.

When taking this medication, some common side effects you might experience include headache, nausea, vomiting, tiredness, muscle pain, or weakness. Bruising, leg pain, and upper respiratory infections might also occur, but these are usually mild and temporary. If they persist or worsen, it’s advisable to consult your healthcare provider for guidance.

There are other side effects that, while less common, are important to be aware of. These include swelling in the arms and legs, joint pain, and pain in the arms and legs. If you experience unusual tiredness, unexplained weight gain, cold intolerance, or changes in your heartbeat, you should seek medical advice as these symptoms can indicate more serious conditions.

Serious side effects, though rare, demand immediate medical attention. These include persistent nausea or vomiting, a severe headache, seizure, changes in vision, or severe stomach pain. There are also risks associated with lung or breathing problems, especially in children with Prader-Willi syndrome, characterized by symptoms like heavy snoring or irregular breathing during sleep.

In very rare cases, the medication might cause allergic reactions, presenting symptoms like a rash, severe swelling of the face, tongue, or throat, dizziness, and breathing difficulties. Additionally, there is a slight increase in the risk of developing tumors or cancer. If any severe symptoms or unusual effects occur, reach out to your healthcare provider promptly for further evaluation and care.