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This medication, while beneficial for managing irregular heartbeats, can sometimes lead to a new, serious irregular heartbeat. Therefore, it is crucial to discuss the potential benefits and risks with your healthcare provider. Below is essential safety and warning information regarding this medication.

• Hospital Monitoring: When beginning treatment, your doctor may advise hospitalization for monitoring and emergency treatment if necessary.

• Increased Mortality Risk Post-Heart Attack: Studies indicate that certain antiarrhythmic drugs may be life-threatening if used post-heart attack. Disopyramide (Norpace) is generally reserved for those with life-threatening arrhythmias. Your heart specialist will decide the best treatment based on your symptoms and EKG results.

• Heart Function Concerns: Disopyramide (Norpace) may reduce heart function, potentially causing or worsening heart failure or leading to low blood pressure. Those with severe heart failure or low blood pressure should avoid this medication unless their arrhythmia condition causes these symptoms. Symptoms like dizziness, fainting, or swelling should be reported immediately to your healthcare provider.

• Abnormal Heart Rhythm: This medication can alter heart electrical activity, possibly leading to serious arrhythmias or heart block. Regular EKG monitoring is essential. Seek medical help if experiencing abnormal heart rates, chest pain, or fainting.

• Low Blood Sugar Risk: Rarely, this medication may cause low blood sugar, especially in individuals with heart failure, poor nutrition, or liver/kidney issues, and those taking other blood sugar-lowering drugs or consuming alcohol. Be alert to symptoms like dizziness or mood changes.

• Conditions Requiring Caution: Disopyramide (Norpace) may exacerbate conditions like glaucoma, myasthenia gravis, or urinary retention. Discuss any family history of these conditions with your provider, as additional monitoring may be needed.

• Kidney or Liver Function: Poor kidney or liver function can lead to accumulation of the drug, increasing side effects. Ensure your provider is aware of any history of kidney or liver problems.

• Potassium Level Monitoring: Abnormal potassium levels can affect the medication's efficacy and side effect profile. Regular blood tests may be needed to monitor these levels.

• Drug Interactions: Disopyramide (Norpace) can interact with other medications, altering its effectiveness or increasing side effects. Inform your provider and pharmacist of all medications you are taking.

Contraindications: Avoid this medication if you have conditions such as cardiogenic shock, second- or third-degree heart block, or long QT syndrome. Always consult your healthcare provider before starting this medication if any contraindications apply to you.

When taking this medication, some individuals may encounter common side effects, which are often mild and temporary. These include dry mouth, constipation, nausea, and abdominal discomfort such as pain, gas, or bloating. Other possible effects are blurred vision, dizziness, dry nose, eyes, or throat, and issues with urination, such as difficulty starting or stopping, frequent urges, or trouble maintaining flow. Although these symptoms can be bothersome, they typically improve over time.

In addition to these, some users might experience fatigue, muscle weakness, headache, or general feelings of unwellness. Less common but possible effects are erectile dysfunction, low blood pressure, and appetite changes. If any of these symptoms persist or worsen, it's advisable to consult with a healthcare provider.

More serious side effects, although rare, require immediate medical attention. These include symptoms of heart failure, such as shortness of breath, swelling of the ankles or feet, and sudden weight gain. Abnormal heart rhythms, low blood pressure, and associated symptoms like chest pain, dizziness, or fainting are also critical. Furthermore, severe allergic reactions marked by rash, itching, swelling, or trouble breathing should be addressed urgently.

If you notice any other unusual effects, even if not listed here, it's important to seek medical advice to ensure your safety and well-being.

Disopyramide (Norpace) can interact with various medications, which may influence its effectiveness or increase the risk of side effects. It is crucial to inform your healthcare provider about all the medications and supplements you are taking, including prescription drugs, over-the-counter products, vitamins, and herbal supplements.

Some medications should not be used with Disopyramide due to significant interaction risks. These include Bepridil, Cisapride, Dronedarone, Fingolimod, Itraconazole, Ketoconazole, Levomethadyl, Mesoridazine, Pimozide, Piperaquine, Posaconazole, Sparfloxacin, Terfenadine, Thioridazine, Vernakalant, and Ziprasidone. Your doctor may choose to avoid prescribing Disopyramide or adjust your other medications accordingly.

There are also drugs that usually should not be combined with Disopyramide, though exceptions may be made if necessary. In such cases, your physician might modify the dosages or frequency of use for one or both medicines. These drugs include Ajmaline, Alfuzosin, Amiodarone, Amisulpride, Amitriptyline, Amoxapine, Anagrelide, Apomorphine, Aprindine, Aripiprazole, Aripiprazole Lauroxil, Arsenic Trioxide, Asenapine, Astemizole, Atazanavir, Azithromycin, Bedaquiline, Betaxolol, Buprenorphine, Buserelin, Ceritinib, Chloral Hydrate, Chloroquine, Chlorpromazine, Chlorpropamide, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clozapine, Cobicistat, Crizotinib, Cyclobenzaprine, Dabrafenib, Dasabuvir, Dasatinib, Degarelix, Delamanid, Desipramine, Deslorelin, Deutetrabenazine, Dofetilide, Dolasetron, Domperidone, Donepezil, Doxepin, Droperidol, Efavirenz, Eliglustat, Encorafenib, Enflurane, Entrectinib, Erythromycin, Escitalopram, Etravirine, Flecainide, Fluconazole, Fluoxetine, Formoterol, Foscarnet, Fostemsavir, Gatifloxacin, Gemifloxacin, Glasdegib, Glimepiride, Glipizide, Glyburide, Gonadorelin, Goserelin, Granisetron, Halofantrine, Haloperidol, Halothane, Histrelin, Hydroquinidine, Hydroxychloroquine, Hydroxyzine, Ibutilide, Iloperidone, Imipramine, Inotuzumab Ozogamicin, Isoflurane, Isradipine, Ivabradine, Ivosidenib, Lacosamide, Lapatinib, Lefamulin, Lenvatinib, Levofloxacin, Lidocaine, Lidoflazine, Lofexidine, Lorcainide, Lumefantrine, Macimorelin, Mefloquine, Methadone, Metronidazole, Mexiletine, Mifepristone, Mirtazapine, Moxifloxacin, Nafarelin, Nalidixic Acid, Nilotinib, Norfloxacin, Nortriptyline, Octreotide, Ofloxacin, Ombitasvir, Ondansetron, Osilodrostat, Osimertinib, Oxaliplatin, Ozanimod, Paliperidone, Panobinostat, Paritaprevir, Pasireotide, Pazopanib, Pentamidine, Pimavanserin, Pirmenol, Pitolisant, Ponesimod, Prilocaine, Probucol, Procainamide, Prochlorperazine, Promethazine, Propafenone, Protriptyline, Quetiapine, Quinidine, Quinine, Ribociclib, Risperidone, Selpercatinib, Sertindole, Sertraline, Sevoflurane, Simeprevir, Siponimod, Sodium Phosphate, Sodium Phosphate, Dibasic, Sodium Phosphate, Monobasic, Solifenacin, Sorafenib, Sotalol, Spiramycin, Sulfamethoxazole, Sulpiride, Sultopride, Sunitinib, Tacrolimus, Telavancin, Telithromycin, Tetrabenazine, Tolazamide, Tolbutamide, Toremifene, Trazodone, Triclabendazole, Trifluoperazine, Trimethoprim, Trimipramine, Triptorelin, Vandetanib, Vardenafil, Vemurafenib, Vinflunine, Voclosporin, Voriconazole, Zolmitriptan, Zotepine, and Zuclopenthixol.

Additionally, some medications might increase the risk of side effects when used with Disopyramide, but they might still be the best treatment option for you. In these instances, your healthcare provider may adjust the dosage or frequency of usage for these medications, which include Atenolol, Dalfopristin, Digoxin, Fosphenytoin, Nevirapine, Phenytoin, Propranolol, Quinupristin, Rifampin, Rifapentine, Ritonavir, and Warfarin.