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This safety information provides crucial details regarding the use of Olopatadine (Pataday) and the associated risks. It is essential to follow these guidelines carefully and consult with your healthcare provider for any concerns.

• Exclusive Eye Use: Olopatadine (Pataday) is intended solely for ocular use. Do not administer this medication in any other manner. In the event of oral ingestion, seek immediate medical assistance or contact the Poison Control Center at 1-800-222-1222.

• Risk of Eye Infections: Contamination of the Olopatadine (Pataday) bottle can lead to eye infections, such as bacterial keratitis, which affects the cornea. Ensure your hands are clean before use and avoid contact between the dropper tip and your eye, hands, or any surfaces to prevent contamination.

• Contact Lens Precaution: If you use contact lenses, remove them before applying Olopatadine (Pataday) drops. Reinsert your lenses at least 10 minutes after administering the drops.

This guidance is designed to ensure safe and effective use of the medication. Adhering to these precautions can help mitigate potential risks.

Common side effects:

• Headache
• Blurred vision
• Dryness or redness of the eye
• Sensation that something is in the eye
• Burning or stinging
• Eyelid swelling

Less common but important to monitor:

• Change in taste
• Feeling of dryness in the eyes

Serious side effects:

• Severe allergic reactions
• Rash
• Itching
• Swelling (particularly of the face, tongue, or throat)
• Severe dizziness
• Trouble breathing

Olopatadine is an antihistamine commonly used to treat allergic conditions such as hay fever and conjunctivitis. While it is generally well-tolerated, it's important to be aware of potential interactions with other substances:

• Central Nervous System (CNS) Depressants: Combining olopatadine with alcohol or other CNS depressants—such as sedatives, tranquilizers, sleeping pills, prescription pain medications, seizure medications, muscle relaxants, or certain anesthetics—can enhance drowsiness and impair alertness. This combination may lead to increased sedation, making activities like driving or operating machinery hazardous. It's advisable to avoid concurrent use of these substances while taking olopatadine.

• Herbal Supplements: Licorice, a common herbal supplement, may influence the metabolism of drugs processed by the liver enzyme CYP3A4, potentially affecting the levels of medications like olopatadine. Due to varying effects observed with different licorice species, it's recommended to use licorice cautiously if you're taking olopatadine.

• Other Medications: Olopatadine may interact with a wide range of medications, including anticoagulants (blood thinners), certain antibiotics, antifungal agents, and other antihistamines. These interactions can alter the effectiveness of olopatadine or increase the risk of side effects. Therefore, it's crucial to inform your healthcare provider about all medications and supplements you're currently using to assess potential interactions.

While olopatadine is primarily metabolized by the liver enzyme CYP3A4, studies indicate that it does not significantly inhibit this enzyme. This suggests a lower likelihood of olopatadine causing drug-drug interactions through this metabolic pathway.

To ensure safe use of olopatadine, always consult your healthcare provider before starting or stopping any medications or supplements. They can provide personalized advice based on your specific health profile and current treatments.