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The following safety information provides essential warnings about the use of this medication. It is important to understand these risks and speak with your healthcare provider if you have any questions or concerns.

• Effects in Young Children: Antihistamines, such as cyproheptadine, may reduce alertness in young children. In some cases, it can cause increased excitement instead.

• Extreme Sleepiness: Cyproheptadine may lead to significant drowsiness, impacting activities like driving or operating machinery. This drowsiness can persist for several hours post-dose. Combining cyproheptadine with alcohol or other sedative medications (e.g., hypnotics, sedatives, tranquilizers, antianxiety drugs) may further impair brain function. Older adults are particularly susceptible to side effects like dizziness, sleepiness, and low blood pressure when using cyproheptadine.

• Caution in Other Health Conditions: If you have conditions such as asthma, increased eye pressure, an overactive thyroid, heart disease, or high blood pressure, inform your healthcare provider before starting cyproheptadine, as it may exacerbate these conditions.

• Contraindications: Avoid using this medication under the following circumstances, as it might cause severe health issues:

  • In newborns or premature infants
  • During breastfeeding
  • When taking monoamine oxidase inhibitors (MAOIs)
  • If you have angle-closure glaucoma
  • With certain stomach ulcers
  • With prostate enlargement symptoms
  • In cases of bladder or stomach blockage
  • If you are an older adult who is ill or feeling weak

Ensure you discuss any pre-existing conditions or medications with your healthcare provider to avoid potential adverse effects.

Common side effects:

• Sleepiness
• Dizziness
• Loss of coordination
• Confusion
• Blurred vision
• Low blood pressure
• Difficulty urinating
• Dryness of the nose, throat, and mouth

Less common but important to monitor:

• Restlessness
• Tremor
• Hallucinations
• Trouble sleeping (insomnia)
• Excitement
• Rash
• Fast heartbeat
• Nausea and vomiting
• Weight gain

Serious side effects:

• Hallucinations
• Slowed brain function
• Seizures
• Fast heartbeat
• Wide pupils
• Breathing problems
• Excessive sleepiness
• Excessive dizziness

When taking cyproheptadine, it's important to be aware of potential interactions with other substances that can affect its effectiveness or increase the risk of side effects. Here are some key considerations:

Drug Interactions:

• Monoamine Oxidase Inhibitors (MAOIs): Combining cyproheptadine with MAOIs, which are used to treat depression or Parkinson's disease, can intensify anticholinergic effects, leading to increased drowsiness, dry mouth, and other side effects.

• Other Antihistamines: Using cyproheptadine alongside other antihistamines, such as diphenhydramine or Cetirizine, may enhance sedative effects, resulting in increased drowsiness and impaired coordination.

• Central Nervous System (CNS) Depressants: Combining cyproheptadine with CNS depressants like sedatives, tranquilizers, or certain medications for anxiety can lead to heightened sedation and drowsiness.

Alcohol Interaction:

• Consuming alcohol while taking cyproheptadine can amplify side effects such as dizziness, drowsiness, and difficulty concentrating. It's advisable to avoid or limit alcohol intake during treatment.

Herbal Supplements:

• Certain herbal supplements, like St. John's Wort, may interact with cyproheptadine, potentially increasing side effects such as drowsiness and dizziness.

Medical Conditions:

• Inform your healthcare provider if you have conditions like high blood pressure, glaucoma, asthma, stomach ulcers, hyperthyroidism, enlarged prostate, or heart problems, as cyproheptadine may exacerbate these conditions.

Always consult your healthcare provider before starting or stopping any medications or supplements while on cyproheptadine to ensure safe and effective treatment.