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This safety and warning guide provides critical information regarding the use of Necon 7/7/7, highlighting potential risks, necessary precautions, and specific instructions for use. It is important to review these details carefully and consult a healthcare professional if there are any concerns.

• Heart Problems and Strokes: The risk of serious heart issues is increased with smoking while taking Necon 7/7/7, especially in individuals over 35 years of age. The risk escalates with the number of cigarettes smoked. Therefore, women over 35 who smoke are advised against using this medication. Factors that can increase risk include heavy smoking, high blood pressure, high cholesterol, obesity, and diabetes.

• Blood Clots: Necon 7/7/7 can elevate the risk of blood clots, particularly during the first year of use or when restarting after a break of four weeks or more. Those undergoing surgery, experiencing prolonged immobility, or who have recently given birth are at higher risk. Discontinuation of the medication is advised at least 4 weeks before and for 2 weeks after surgery or during periods of bed rest. It should not be resumed until 4 weeks postpartum if not breastfeeding. Be alert for symptoms like sharp chest pain, coughing up blood, shortness of breath, or leg pain, as these may indicate a blood clot.

• High Blood Sugar and Cholesterol: This medication may raise blood sugar and cholesterol levels. Individuals with diabetes, prediabetes, or high cholesterol should consult their healthcare provider before starting Necon 7/7/7. Regular monitoring will be necessary for those who choose to proceed with its use.

• High Blood Pressure: Necon 7/7/7 can increase blood pressure, particularly in older individuals or those on long-term birth control. Women with significantly high blood pressure should avoid hormonal contraceptives like Necon 7/7/7. Should blood pressure rise above 160/100 mmHg and remain uncontrolled, it is advised to discuss alternative contraceptive options with a healthcare provider.

• Breast and Cervical Cancer Risk: There is an indication that Necon 7/7/7 may increase the risk of breast and cervical cancer, particularly in those with a history of breast cancer or long-term use of combined oral contraceptives (COCs).

• Liver Problems: Individuals with liver conditions, such as viral liver infections, severe liver scarring, or liver tumors, should not use Necon 7/7/7. The medication could increase the risk of benign liver tumors. If symptoms like jaundice, fever, fatigue, loss of appetite, or dark urine occur, discontinue use and seek medical advice promptly.

Contraindications: Necon 7/7/7 is contraindicated in the following conditions:

• Current or past blood clots.
• Conditions predisposing to blood clots.
• History of heart attack or stroke.
• Heart valve issues with complications.
• Persistent high blood pressure (systolic >160 mmHg or diastolic >100 mmHg).
• Diabetes with vascular complications.
• Severe headaches with neurological symptoms.
• Major surgery with prolonged immobility.
• Current or past breast cancer.
• Uterine lining cancer.
• Estrogen-sensitive tumors.
• Undiagnosed abnormal vaginal bleeding.
• Jaundice during pregnancy or previous use.
• Liver issues or liver cancer.
• Pregnancy.
• Use of hepatitis C medications containing ombitasvir, paritaprevir, ritonavir, with or without dasabuvir.

If you are experiencing any of these conditions, consult your healthcare provider for suitable alternatives.

Common side effects:

• Nausea
• Vomiting
• Stomach cramps
• Bloating
• Bleeding between periods
• Spotting
• Changes in menstrual flow
• Missed periods

Serious side effects:

• Symptoms of a heart attack (chest pain or dizziness)
• Signs of a stroke (sudden numbness or difficulty speaking)
• Deep vein thrombosis (leg pain and swelling)
• Pulmonary embolism (chest pain and difficulty breathing)

When taking Pirmella 7/7/7, it's important to be aware of potential interactions with other medications, supplements, and certain foods, as these can affect the effectiveness of the contraceptive or increase the risk of side effects.

Medications That May Decrease Effectiveness:

Some drugs can reduce the levels of hormones in Pirmella 7/7/7, potentially making it less effective at preventing pregnancy. These include:

• Antibiotics: Rifampin, Rifabutin, and rifapentine.
• Anticonvulsants: Phenobarbital, Phenytoin, Carbamazepine, Oxcarbazepine, Topiramate, and Felbamate.
• Antifungal Agents: Griseofulvin.
• HIV Medications: Certain protease inhibitors and non-nucleoside reverse transcriptase inhibitors.
• Herbal Supplements: St. John's wort.

If you're prescribed any of these, discuss alternative or additional contraceptive methods with your healthcare provider.

Medications That May Increase Hormone Levels:

Other substances can raise hormone levels, potentially leading to increased side effects. These include:

• Antifungal Medications: Itraconazole, Ketoconazole, Voriconazole, and Fluconazole.
• HIV Medications: Atazanavir and indinavir.
• Statins: Atorvastatin and Rosuvastatin.
• Vitamin C (Ascorbic Acid): High doses.
• Acetaminophen: Commonly used for pain relief.

Be vigilant for symptoms like nausea, vomiting, or unusual vaginal bleeding if you're taking these alongside Pirmella 7/7/7, and consult your doctor if they occur.

Food Interactions:

Grapefruit juice can increase the levels of ethinyl estradiol in your body, potentially leading to more pronounced side effects. It's advisable to limit or avoid grapefruit juice while taking Pirmella 7/7/7.

Other Considerations:

Combining Pirmella 7/7/7 with certain Hepatitis C treatments, specifically those containing ombitasvir/paritaprevir/Ritonavir, with or without dasabuvir, can lead to significant liver enzyme elevations. It's recommended to discontinue Pirmella before starting such treatments and consult your healthcare provider for guidance.

Always inform your healthcare provider about all medications, supplements, and herbal products you're using to ensure Pirmella 7/7/7 remains safe and effective for you.