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Eltrombopag, marketed under the brand name Promacta, is associated with several important safety concerns. If you are prescribed this medication, it is crucial to be aware of the potential risks and necessary precautions. Below are key points to consider:

• Liver Damage: Eltrombopag can potentially lead to severe liver issues, which may be life-threatening. This risk is elevated for individuals with chronic hepatitis C, especially when combined with ribavirin and interferon. Regular liver function tests will be required before and during treatment to monitor liver health. Seek immediate medical attention if you experience persistent nausea, vomiting, loss of appetite, abdominal pain or swelling, dark urine, yellowing of the skin or eyes, or any changes in mental state.

• Blood Clots: The medication may increase the risk of blood clots due to elevated platelet levels. Those over 65, smokers, individuals with a history of blood clots, obesity, or reduced physical activity are at heightened risk. Regular blood tests are necessary to monitor for potential clotting issues. Symptoms such as abdominal pain, nausea, vomiting, and diarrhea may indicate a liver blood clot, requiring urgent medical care.

• Blood Cancer Risk in MDS: Patients with myelodysplastic syndromes (MDS) taking eltrombopag have a higher risk of developing acute myeloid leukemia (AML), a severe form of blood cancer. Discuss any history of MDS or blood cancers with your healthcare provider prior to starting treatment.

• Cataracts: There is a possibility of developing or worsening cataracts while on eltrombopag. Risks are higher for those over 65, smokers, individuals with diabetes, high blood pressure, or those with a history of prolonged steroid use. Eye examinations are advised before and during treatment. Report any visual disturbances, such as blurred vision or difficulty seeing at night, to your doctor promptly.

Your healthcare provider will guide you on the appropriate monitoring and any specific precautions necessary during your treatment with eltrombopag. Always discuss the benefits and potential risks of this medication with your doctor.

When taking this medication, some individuals may experience common side effects such as nausea, diarrhea, headache, muscle pain, and tingling or numbness. These are often mild and temporary, but if they persist or worsen, it is important to consult your healthcare provider. Other common side effects include fever, tiredness, and cough. In some cases, these effects may be more prevalent, such as low red blood cell levels (anemia), which can occur in about 40% of users.

While many people do not experience serious side effects, it is crucial to be aware of them. Rare but severe reactions include vision changes, new or worsening cloudiness in the eye (cataracts), and serious problems from blood clots, which could lead to heart attack, stroke, or clots in the lungs or legs. Symptoms like shortness of breath, chest pain, sudden dizziness, or weakness on one side of the body require immediate medical attention.

Additionally, allergic reactions to this medication are rare but can be serious. Seek urgent medical help if you notice symptoms such as rash, itching, severe dizziness, or trouble breathing. Be attentive to any rashes as they can sometimes indicate a severe reaction. Always inform your healthcare provider if you experience any side effects, even those not listed here.

When taking Promacta (eltrombopag), it's important to be aware of its potential interactions with other drugs and supplements. Inform your doctor and pharmacist about all medications, including prescription, over-the-counter, vitamins, and herbal supplements you are using.

Some medications should not be taken with Promacta at all, as they can interfere with its effectiveness or increase the risk of side effects. These include Elagolix and Grazoprevir. Your doctor might choose an alternative treatment or adjust your current medications accordingly.

There are other medications that may require careful consideration if taken with Promacta. Although usually not recommended, certain situations might necessitate their use together. In such cases, your doctor may need to adjust the dosage or frequency of one or both drugs. These medications include Alpelisib, Aluminum, Berotralstat, Calcium, Eluxadoline, Iron, Magnesium, Ozanimod, Pexidartinib, Pixantrone, Revefenacin, Rimegepant, Selenium, Simvastatin, Topotecan, Ubrogepant, and Zinc.

Additionally, using Promacta with some medications might increase the likelihood of side effects. Despite this, the combination might still be the best treatment option. Your doctor will likely adjust the dosage or usage frequency to manage any risks. Medications in this category include Atorvastatin, Bosentan, Ezetimibe, Fluvastatin, Glyburide, Imatinib, Irinotecan, Lapatinib, Letermovir, Lopinavir, Methotrexate, Mitoxantrone, Olmesartan, Pitavastatin, Pravastatin, Repaglinide, Rifampin, Rosuvastatin, Sulfasalazine, Tenofovir Alafenamide, and Valsartan.

Moreover, Promacta may affect certain laboratory tests, specifically those measuring creatinine and bilirubin levels, potentially leading to false results. It's crucial to inform lab personnel and all healthcare providers that you are using Promacta to ensure accurate test outcomes.