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When considering the use of Rayaldee (calcifediol), it is crucial to understand the associated safety warnings to ensure its safe and effective use. Carefully review the following points and consult your healthcare provider if you have any concerns or questions.

• Elevated Blood Calcium Levels: Rayaldee may cause an increase in blood calcium levels, which can lead to serious issues such as heart rhythm disturbances, vascular problems, and seizures. The likelihood of this occurring increases if you are taking high doses of calcium supplements, certain diuretics, or other vitamin D products. Avoid using additional vitamin D or calcium supplements unless advised by your healthcare provider.

• Interaction with Digoxin: If you are concurrently taking digoxin and Rayaldee, be aware that elevated calcium levels could increase the risk of digitalis toxicity due to digoxin accumulation. Symptoms to watch for include confusion, irregular heartbeat, nausea, or vision changes. Your healthcare provider will monitor your calcium levels closely to manage this risk.

• Bone Health Concerns: Rayaldee can excessively lower parathyroid hormone (PTH) levels, potentially leading to weakened bones and an increased risk of fractures. Regular monitoring of PTH levels via blood tests will help ensure they remain within a healthy range, and your dosage may be adjusted accordingly.

Consult your healthcare provider immediately if you experience any adverse symptoms or have questions about these risks. Always follow your healthcare provider's guidance regarding the use of additional supplements or medications.

Calcifediol is generally well-tolerated, with most individuals experiencing minimal side effects. Common, mild side effects may include symptoms similar to a common cold, such as coughing and shortness of breath, as well as anemia, high creatinine levels, constipation, and high potassium levels. While these effects are often not severe, it is advisable to consult your healthcare provider if they persist or worsen.

There are other side effects that may occur, such as high uric acid levels, arthritis, bruising, pneumonia, and chronic obstructive pulmonary disease (COPD). These are less common, and while they may not be immediately severe, it is important to monitor their progression and seek medical advice if necessary.

Serious side effects, though rare, require immediate medical attention. These include high blood phosphorus levels, which can lead to muscle cramps, bone or joint pain, itchy skin, rash, and tingling sensations. High blood calcium levels, characterized by fatigue, muscle weakness, loss of appetite, nausea, vomiting, constipation, bone pain, depression, and confusion, are also serious and necessitate prompt medical care.

Additionally, although a severe allergic reaction to Calcifediol is rare, it is critical to seek emergency medical help if symptoms like rash, severe dizziness, swelling, or trouble breathing occur. Always remain vigilant for any unusual symptoms and consult your healthcare provider for guidance.