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Calcifediol usually has very few side effects. If you have any unusual side effects, contact your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: bone/joint/muscle pain, loss of appetite, nausea/vomiting, constipation, increased thirst, increased urination, fast/slow/irregular heartbeat, mental/mood changes (such as difficulty thinking clearly), weakness. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

A product that may interact with this drug is: burosumab. Calcifediol is very similar to other forms of vitamin D. Do not use medications containing other forms of vitamin D while using calcifediol.