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Methotrexate is used to treat severe psoriasis that has not responded to other treatments or rheumatoid arthritis. It may also be used to treat a certain type of arthritis in children (polyarticular juvenile idiopathic arthritis - pJIA). Methotrexate belongs to a class of drugs known as antimetabolites. It works by blocking the immune system from attacking healthy tissue. Early treatment of rheumatoid arthritis with methotrexate helps to reduce further joint damage and to preserve joint function.