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Nabumetone, a nonsteroidal anti-inflammatory drug (NSAID), carries several important safety warnings and potential risks that should be reviewed carefully. Always discuss any concerns with your healthcare provider to fully understand the benefits and risks associated with this medication.

• Heart Attack and Stroke Risk: Use of nabumetone can increase the risk of heart attack or stroke, especially with prolonged use. This risk is higher in individuals with a history of heart disease or those undergoing heart bypass surgery. It is advised to use nabumetone for the shortest duration necessary. Avoid this medication before or after coronary artery bypass graft surgery (CABG).

• Gastrointestinal Bleeding: Nabumetone may cause serious gastrointestinal issues, including ulcers and bleeding, without warning. Elderly individuals or those with a history of gastrointestinal bleeding or peptic ulcers are at increased risk. Seek immediate medical attention if experiencing persistent stomach pain, blood in vomit, or dark, tarry stools.

• High Blood Pressure: The medication can elevate blood pressure, particularly in those with pre-existing hypertension. Regular monitoring of blood pressure is recommended.

• Heart Failure: Nabumetone may exacerbate heart failure symptoms, such as fluid retention, potentially leading to heart attacks or hospitalizations. Discuss the use of nabumetone with your provider if you have heart failure.

• Kidney and Liver Concerns: There is a potential for decreased kidney function or liver issues with nabumetone. Report symptoms like irregular heartbeat, poor urine output, nausea, fatigue, or yellowing of the skin/eyes to your provider immediately.

• Allergic Reactions: If you have a history of severe allergic reactions to aspirin or other NSAIDs, you may be at risk for similar reactions to nabumetone. Seek urgent medical help if hives, breathing difficulties, or facial swelling occur.

• Serious Skin Reactions: Rare but serious skin reactions, including rashes and blisters, may occur. Discontinue use and consult your healthcare provider if these symptoms appear.

• Pregnancy: Nabumetone is not recommended during pregnancy, particularly in the third trimester, due to potential harm to the unborn child. Discuss safer alternatives with your provider if you are pregnant or planning to become pregnant.

• Anemia Risk: The drug may increase bleeding risks, potentially leading to anemia. Symptoms such as fatigue, pallor, or dizziness should be reported, and regular blood tests may be necessary.

For any signs of overdose or severe reactions, seek immediate medical assistance. Always inform your healthcare provider about your medical history, current medications, and any allergies to ensure safe use of nabumetone.

When using this medication, you may experience some common side effects, which are generally mild. These include upset stomach, nausea, constipation, diarrhea, gas, dizziness, drowsiness, and headache. It’s important to monitor these symptoms and contact a healthcare provider if they persist or worsen. Additionally, some individuals may experience stomach pain or indigestion.

In rare cases, more serious side effects can occur, requiring immediate medical attention. These include liver problems, characterized by persistent nausea, fatigue, diarrhea, yellowing of the skin or eyes, and severe abdominal pain. Kidney issues may present as irregular heartbeat, shortness of breath, reduced urine output, confusion, or weakness. Heart-related concerns such as heart attack or heart failure may manifest through chest pain, shortness of breath, and swelling in the ankles or feet.

Other serious concerns include gastrointestinal bleeding, indicated by black or tarry stools and dizziness, or a stroke, which may cause sudden weakness, slurred speech, or confusion. Severe allergic reactions, although rare, may involve hives, swelling of the face or throat, and difficulty breathing. Serious skin reactions may also occur, presenting as flu-like symptoms, painful rashes, blisters, or peeling of the skin.

While these severe side effects are not common, it’s crucial to seek medical help promptly if they occur. Remember that although many people tolerate the medication well, staying informed and vigilant about potential side effects is key to managing your health effectively.

Nabumetone can interact with various medications, so it's important to inform your doctor and pharmacist about all drugs you are currently taking, including prescriptions, over-the-counter medications, and supplements. Some drugs should not be used with nabumetone, such as ketorolac, due to the potential for serious interactions.

Additionally, nabumetone can be used with caution alongside other medications like abciximab, aspirin, clopidogrel, and various anticoagulants, as these can increase the risk of bleeding. Diuretics like furosemide, lithium, methotrexate, and corticosteroids like prednisone may also interact, requiring careful monitoring.

If you are taking ACE inhibitors, angiotensin II receptor blockers, or certain beta-blockers, your doctor may need to adjust your medication to avoid increased side effects. Always consult your healthcare provider for guidance tailored to your specific situation.