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This section outlines critical safety information about the potential risks of using riluzole (Rilutek). Please review these warnings carefully and consult your healthcare provider with any questions or concerns.

• Liver Injury and Damage: Riluzole (Rilutek) may affect liver function and, in some cases, lead to severe liver damage. It is crucial to undergo blood tests both before starting and during treatment to ensure your liver is functioning correctly. Contact your healthcare provider immediately if you experience symptoms such as fever, rash, loss of appetite, stomach pain, dark urine, or yellowing of the skin or eyes. Individuals with a history of liver damage or disease, or those taking other liver-affecting medications, are at increased risk.

• Low White Blood Cell Count: This medication can, in rare instances, significantly lower white blood cell counts, compromising the body’s ability to combat infections. Symptoms include fatigue, fevers, sore throat, or infections. Notify your healthcare provider promptly if you experience any of these symptoms.

• Lung Disease: Although extremely rare, there is a possibility of developing lung disease while on riluzole (Rilutek). If you notice a persistent dry cough or difficulty breathing, contact your healthcare provider immediately, as discontinuation of the medication may be necessary. This risk is heightened for individuals with a history of lung disease.

There are no contraindications currently available for riluzole (Rilutek). Always discuss any medical concerns or pre-existing conditions with your healthcare provider before starting a new medication.

Common side effects:

• Dizziness
• Drowsiness
• Nausea
• Vomiting
• Numbness or tingling around the mouth
• Body weakness
• Stomach pain
• Dry mouth
• Joint pain
• Trouble sleeping
• Itching

Less common but important to monitor:

• Fast heartbeat
• Signs of liver problems
• Loss of appetite
• Yellowing of the skin or eyes
• Dark urine
• Signs of low white blood cell count
• Frequent infections
• Sore throat
• Fever
• Extreme fatigue
• Breathing problems
• Shortness of breath
• Wheezing
• Persistent cough

Serious side effects:

• Severe allergic reaction
• Rash
• Severe dizziness
• Itching or swelling
• Difficulty breathing

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abametapir
• Capmatinib
• Pixantrone