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Upadacitinib is a medication that may compromise your immune system, increasing the likelihood of contracting serious infections, some of which can be life-threatening. The most common severe infections include pneumonia and skin infections. This risk is heightened if you are taking other immune-suppressing drugs like methotrexate or corticosteroids. It is crucial to inform your healthcare provider immediately if you experience any signs of infection, such as persistent sore throat, fever, chills, cough, non-healing skin sores, painful or frequent urination, or white patches in your mouth or on your tongue.

• Infection Precautions: Prior to and during your treatment, a tuberculosis (TB) skin test is necessary. Inform your doctor if you have been in close contact with someone with TB or have traveled to regions where fungal infections like coccidioidomycosis and histoplasmosis are prevalent, such as the Ohio and Mississippi River valleys and the southwestern United States.

• Cancer Risk: Although rare, there is a potential risk of developing cancers such as lymphoma, skin cancer, or lung cancer while using this medication. The risk is higher for current or former smokers. To minimize skin cancer risks, protect your skin by avoiding extended sun exposure, tanning booths, and sunlamps. Always use sunscreen and wear protective clothing outdoors. Promptly report any symptoms to your doctor, such as persistent fever or cough, wheezing, unusual lumps or growths, unexplained weight loss, night sweats, changes in mole appearance or size, or unusual skin changes.

• Blood Clot Risk: Upadacitinib may infrequently lead to serious, sometimes fatal, blood clot issues, including heart attacks, strokes, or clots in the lungs or legs. The risk is greater for individuals who smoke or have smoked, or who are over 50 with at least one heart disease risk factor. Discuss the potential risks and benefits with your doctor. Seek immediate medical assistance if you notice symptoms such as shortness of breath, rapid breathing, chest, jaw, or left arm pain, unusual sweating, confusion, sudden dizziness or fainting, pain, swelling, or warmth in the groin or calf, severe headaches, trouble speaking, weakness on one side of the body, or sudden changes in vision.

When taking this medication, some individuals may experience nausea or headaches. These are common side effects and usually mild, but if they persist or worsen, consult your healthcare provider. It's important to be aware of more serious side effects that can occur, although they are less common. Report any symptoms of anemia, such as unusual fatigue, pale skin, or a rapid heartbeat. Additionally, watch for signs of liver problems like persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, and dark urine. A very serious but rare complication is a tear in the stomach or intestinal wall, which may present as severe and persistent abdominal pain, fever, dizziness, fainting, or severe nausea and vomiting.

Seek immediate medical attention if you experience sudden changes in vision, such as blurriness or seeing flashes of light, as these are considered very serious side effects. Although rare, severe allergic reactions to this medication can occur. Symptoms to watch for include rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, and difficulty breathing. If any of these symptoms arise, seek emergency medical help promptly. This summary does not include all possible side effects, so if you experience any other unusual symptoms, reach out to your healthcare provider for guidance.