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The following safety information outlines important warnings and precautions associated with the use of somatropin injections, such as Omnitrope. It is crucial to review these details and discuss any concerns with your healthcare provider.

• Increased Mortality Risk in Critical Illness: Somatropin injections should not be administered to individuals undergoing open heart or abdominal surgery, those with serious injuries, or those experiencing severe respiratory issues, as it may elevate the risk of mortality in these situations.

• Sudden Death in Children with Prader-Willi Syndrome: Children with Prader-Willi syndrome who are obese, have airway blockages, or unknown respiratory infections should not use somatropin injections due to the risk of sudden death. Close monitoring of respiratory symptoms is advised for children without these risk factors, and medical consultation is recommended if breathing difficulties or increased snoring occur.

• Severe Allergic Reactions: Life-threatening allergic reactions, including anaphylaxis, may occur. Seek immediate medical attention if symptoms such as dizziness, choking, difficulty breathing, or facial swelling are experienced.

• Cancer Risks: Avoid somatropin injections if there is an active tumor or cancer history. The medication may increase the risk of new or worsening cancers. Report any behavioral changes, headaches, vision changes, or skin color alterations to your provider.

• Hyperglycemia Risk: Somatropin may cause elevated blood sugar levels, increasing the risk of diabetes, especially in individuals with obesity, Turner syndrome, or a familial diabetes history. Regular blood sugar monitoring and potential medication adjustments may be necessary.

• Intracranial Hypertension: Some users may develop increased brain pressure, leading to symptoms like vision changes, headaches, nausea, and vomiting. These symptoms typically resolve upon discontinuation or dosage adjustment of the medication.

• Fluid Retention: Somatropin can cause fluid retention, leading to swelling in limbs and conditions like muscle pain and carpal tunnel syndrome. Notify your provider if these symptoms develop.

• Cortisol Level Reduction: Somatropin may lower cortisol levels, particularly in individuals taking steroid hormones. This can affect stress and inflammation responses.

• Bone Issues in Children: There is a risk of thigh bone displacement in rapidly growing children. Report any knee or hip pain or limping to your healthcare provider.

• Pancreatitis Risk: Although rare, somatropin may cause pancreatitis, indicated by symptoms such as nausea, vomiting, and abdominal pain radiating to the back. Discontinue use and seek immediate medical help if these symptoms occur.

Contraindications: Avoid using somatropin if you have any of the following conditions, as they may pose serious health risks:

• Critical illness from surgery, injuries, or severe respiratory issues.
• Active cancer.
• Severe diabetic eye damage.
• Prader-Willi syndrome in children with severe obesity or respiratory issues.
• Children who have completed growth.

Always consult your healthcare provider before starting or discontinuing somatropin therapy.

When taking this medication, some individuals may experience mild side effects such as headaches, nausea, vomiting, tiredness, muscle pain, or weakness. These symptoms are generally manageable but should be reported to a healthcare provider if they persist or worsen. Other common side effects include bruising, leg pain, and joint pain, with swelling in the arms and legs and upper respiratory infections also reported in some users. These effects usually do not pose significant health risks but should be monitored.

Serious side effects, though rare, demand immediate medical attention. These include persistent nausea or vomiting, unusual tiredness, rapid or slow heartbeat, significant weight changes, cold intolerance, ear problems, joint pain, numbness, increased thirst or urination, and severe stomach or abdominal pain. It is vital to seek urgent care if experiencing vision changes, seizures, or severe headaches.

In children with Prader-Willi syndrome, this medication may rarely cause potentially fatal lung or breathing problems, especially in males, those who are severely overweight, or those with existing lung issues. Signs include heavy snoring, irregular breathing during sleep, or symptoms of lung infection such as fever and cough. Furthermore, there is a potential increased risk of tumor development, so discussing risks and benefits with a healthcare provider is crucial.

A very serious allergic reaction is rare but requires immediate medical help if symptoms such as rash, severe swelling of the face, tongue, or throat, dizziness, or breathing difficulties occur. Always contact a healthcare professional if unusual side effects arise.