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Brodalumab, a medication used for specific conditions, comes with important safety and warning information that must be reviewed before use. Below are key points to consider for ensuring safe use:

• Mental Health Risks: Though rare, brodalumab may cause severe mental health changes, including depression and suicidal thoughts or attempts. Immediate medical attention is required if symptoms such as depression, anxiety, or suicidal thoughts occur. Individuals in the United States must adhere to the REMS Program requirements for brodalumab. For those in other countries, consult local healthcare professionals for relevant regulations.

• Suicidal Thoughts and Behavior: A few individuals taking Siliq (brodalumab) have committed suicide, though a direct link to the medication has not been established. Those with a history of depression or suicidal thoughts should only use this medication if the potential benefits outweigh the risks, as determined by their healthcare provider. It's crucial to contact your healthcare provider immediately if you experience suicidal thoughts, anxiety, panic attacks, insomnia, irritability, or restlessness.

• Serious Infections: Brodalumab can increase the risk of serious or life-threatening infections, especially in individuals with chronic conditions. Symptoms like fever, persistent cough, difficulty breathing, night sweats, or confusion require prompt medical evaluation. Do not use brodalumab if you have an active infection.

• Crohn's Disease: Brodalumab is contraindicated for individuals with Crohn's disease, as it may exacerbate symptoms or even trigger the onset of the disease in those previously unaffected. Symptoms such as unexplained diarrhea, fever, stomach pain, weight loss, and fatigue should be reported to a healthcare provider, and discontinuation of the medication may be necessary.

For any concerns about the use of brodalumab, especially regarding pre-existing conditions or potential interactions with other substances, it is essential to consult a healthcare professional. In case of suspected overdose, seek emergency medical assistance immediately.

When using this medication, some individuals may experience common side effects, which are usually mild and include joint pain, headaches, low energy, diarrhea, sore throat, nausea, muscle pain, and reactions at the injection site. Cold symptoms, such as a runny or stuffy nose and cough, may also occur. If these effects persist or worsen, it's advisable to consult your healthcare provider for guidance.

Other side effects, while less common, include flu-like symptoms, a low white blood cell count, and fungal infections of the skin, such as athlete’s foot or jock itch. If you experience these, especially if they become severe, it is important to contact your healthcare provider.

There are also rare but serious side effects that require immediate medical attention. These include signs of serious infections, such as fever, persistent cough, night sweats, confusion, extreme tiredness, chills, and diarrhea with blood or mucus. Another critical concern is any indication of suicidal thoughts or behaviors.

Additionally, although a very serious allergic reaction is rare, it is crucial to seek emergency medical help if you notice symptoms such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing. If you observe any other effects not listed, it is essential to reach out to your healthcare provider.