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When considering treatment with Skyrizi (risankizumab-rzaa) at a 150 mg dose, it's important to be aware of certain safety warnings and potential risks:

Serious Allergic Reactions: Some individuals may experience severe allergic reactions to Skyrizi, including anaphylaxis. Symptoms can include fainting, dizziness, swelling of the face or throat, difficulty breathing, chest tightness, skin rash, hives, or itching. If any of these occur, discontinue use immediately and seek emergency medical attention.

Increased Risk of Infections: Skyrizi may lower your immune system's ability to fight infections, potentially increasing your risk. Before starting treatment, your healthcare provider should check for existing infections and tuberculosis (TB). If you have a history of chronic or recurrent infections, discuss the risks and benefits with your provider. During treatment, monitor for signs of infection, such as fever, chills, cough, shortness of breath, muscle aches, or skin sores. If an infection develops, contact your healthcare provider promptly.

Tuberculosis (TB): Prior to initiating Skyrizi, evaluate for TB infection. If you have a history of latent or active TB and an adequate course of treatment cannot be confirmed, consider anti-TB therapy before starting Skyrizi. Monitor for signs and symptoms of active TB during and after treatment. Do not administer Skyrizi to patients with active TB.

Liver Health Concerns: In the treatment of inflammatory bowel diseases like Crohn's disease and ulcerative colitis, there have been reports of drug-induced liver injury. Before starting Skyrizi, your healthcare provider should evaluate liver enzymes and bilirubin levels, and continue monitoring during treatment. If you have evidence of liver cirrhosis, discuss alternative treatments with your provider. Seek immediate medical attention if you experience symptoms suggestive of liver problems, such as unexplained rash, nausea, vomiting, abdominal pain, fatigue, loss of appetite, yellowing of the skin or eyes, or dark urine.

Vaccinations: Avoid using live vaccines while being treated with Skyrizi, as it may increase the risk of infection. Ensure all age-appropriate vaccinations are completed before starting treatment.

Always consult with your healthcare provider to fully understand the potential risks and benefits of Skyrizi, and to determine if it's the right treatment option for you.

Skyrizi (risankizumab-rzaa) is a medication used to treat certain inflammatory conditions, including moderate to severe plaque psoriasis, active psoriatic arthritis, Crohn's disease, and ulcerative colitis. While many individuals tolerate Skyrizi well, it's important to be aware of potential side effects associated with its use. Common Side Effects:

• Upper Respiratory Infections: Symptoms may include a sore throat, nasal congestion, or cough.
• Headache: Some individuals may experience mild to moderate headaches.
• Fatigue: A general feeling of tiredness or lack of energy can occur.
• Injection Site Reactions: Redness, swelling, itching, or pain at the injection site are possible.
• Fungal Skin Infections: Conditions like athlete's foot or ringworm may develop. Serious Side Effects:
• Serious Allergic Reactions: Although rare, signs can include fainting, dizziness, swelling of the face or throat, difficulty breathing, chest tightness, skin rash, hives, or itching. If any of these occur, seek emergency medical attention immediately.
• Infections: Skyrizi may lower the immune system's ability to fight infections, increasing the risk of serious infections. Symptoms to watch for include fever, chills, cough, shortness of breath, muscle aches, weight loss, diarrhea, stomach pain, or burning during urination. Notify your healthcare provider promptly if you experience any of these.
• Liver Problems: Particularly in individuals treated for Crohn's disease or ulcerative colitis, liver issues may arise. Symptoms can include unexplained rash, nausea, vomiting, abdominal pain, fatigue, loss of appetite, yellowing of the skin or eyes (jaundice), and dark urine. Contact your healthcare provider immediately if you notice these signs. It's essential to discuss any concerns or side effects with your healthcare provider to ensure the safe and effective use of Skyrizi.

When taking Skyrizi (risankizumab) at a 150 mg dose, it's important to be aware of potential interactions with other medications and vaccines. Skyrizi modulates the immune system, which can increase the risk of infections when combined with certain treatments.

Live Vaccines: Avoid receiving live vaccines during Skyrizi treatment, as the medication may reduce the effectiveness of these vaccines and increase the risk of infection. Complete all age-appropriate vaccinations before starting Skyrizi therapy.

Immunosuppressive Therapies: Combining Skyrizi with other immunosuppressants, such as corticosteroids or biologic agents, may further suppress the immune system, heightening the risk of serious infections. The safety and efficacy of using Skyrizi alongside other immunosuppressive treatments have not been established.

Other Medications: While Skyrizi is not expected to interact with medications metabolized by liver enzymes, it's essential to inform your healthcare provider about all prescription and over-the-counter drugs, vitamins, and herbal supplements you are taking. This ensures any potential interactions are identified and managed appropriately.

Always consult your healthcare provider before starting or stopping any medications while on Skyrizi to ensure safe and effective treatment.