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When using acitretin, it is crucial for patients to be aware of several important safety precautions and potential risks:

• Pregnancy Risks: Do not take this medication if you are pregnant or planning to become pregnant within three years after stopping the treatment, as it can cause severe birth defects. It is advised to use two effective forms of birth control starting one month before the treatment and continuing for at least three years after stopping. Avoid using non-estrogen "minipills" as they may be ineffective with this medication. Consult your healthcare provider for further guidance.

• Requirements for Women of Childbearing Age: Women capable of becoming pregnant must adhere to strict guidelines before using acitretin. This includes:

  • Testing negative on two pregnancy tests taken one week before starting the medication or at least 11 days following the last unprotected sexual intercourse.
  • Commencing treatment within seven days of the second negative pregnancy test.
  • Having severe psoriasis for which other treatments are unsuitable.
  • Receiving both oral and written instructions on using two methods of contraception during treatment and for three years after completion.
  • Being fully informed of the risks of birth control failure during acitretin use and pregnancy.
  • Undergoing monthly pregnancy tests during treatment and every three months for three years afterward.

• Alcohol Interaction: Avoid consuming alcohol during treatment with acitretin and for two months after stopping, as alcohol can prolong the presence of the drug in the body.

• Potential Risks for Male Patients: The risk to an unborn baby from traces of this medication found in the semen of male patients is not yet known.

• Serious Health Risks: Acitretin can infrequently lead to severe, possibly fatal conditions such as liver disease (hepatitis) and increased brain fluid pressure (pseudotumor cerebri). Seek immediate medical attention if you experience severe or persistent headaches, unrelenting nausea or vomiting, appetite loss, yellowing of the skin or eyes, dark urine, intense abdominal pain, unusual fatigue, or vision changes like blurred or double vision.

• Risk of Pancreatitis: This medication is associated with pancreatitis (pancreas inflammation). Report persistent lower abdominal pain to your physician promptly.

• Mental Health Concerns: Rarely, acitretin can cause serious changes in mood or mental state, even after discontinuation. Contact a healthcare professional immediately if you experience symptoms such as depression, irritability, aggressive or violent behavior, or suicidal thoughts.

These guidelines are designed to ensure safe and effective use of acitretin. Always follow your healthcare provider's instructions and consult them for any concerns.

When beginning this medication, it's common to notice skin changes such as increased redness, itching, scaling, peeling, and dryness. You might also experience dry eyes, irritation, crusting of the eyelids, a dry mouth, skin peeling on your fingertips, palms, or soles, chapped lips, a runny nose, increased thirst, changes in taste, and hair loss. These side effects are generally mild and should improve as your body adjusts. If they persist or worsen, it's important to consult your healthcare provider.

For contact lens wearers, dry eyes might cause discomfort. Serious side effects are uncommon, but you should be aware of them. If you experience decreased night vision, fever, chills, dizziness, bone or joint pain, muscle pain or weakness, difficulty moving, swelling, sudden weight gain, or signs of kidney issues such as changes in urination, seek medical attention promptly.

Allergic reactions to this medication are rare but can be severe. If you notice symptoms such as a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing, it is crucial to seek immediate medical help. This list does not cover all possible side effects, so if you notice any other unusual symptoms, contact your healthcare provider.