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Esketamine must be administered in a healthcare setting, such as a doctor's office or medical clinic. It is crucial to be aware of potential side effects, which include drowsiness, dizziness, fainting, anxiety, and in severe cases, dangerously slow or shallow breathing. You may also experience dissociation, a sensation of being detached from your body, thoughts, feelings, surroundings, and time. Following each treatment session, a healthcare professional will monitor you for at least two hours to ensure that these effects subside and that it is safe for you to leave.

This medication carries a risk of abuse and may lead to physical and psychological dependence. It is important to follow the guidelines provided in the "How to Use" section carefully. In the United States, the use of esketamine is regulated under the REMS Program, which requires your understanding and compliance with specific conditions. If you are outside the United States, consult your doctor and pharmacist to understand the regulations applicable in your country.

Antidepressants, including esketamine, are prescribed for various conditions such as depression and other mental health disorders. They can help prevent suicidal thoughts or attempts and offer other significant benefits. However, studies indicate that a small percentage of individuals, particularly those under 25, may experience worsening depression, new or aggravated mental health symptoms, or suicidal thoughts or actions when using antidepressants. It is crucial to discuss the risks and benefits with your doctor, especially if you are under 25, regardless of whether the treatment is for a mental health condition.

Contact your doctor immediately if you notice any signs of worsening depression, other psychiatric conditions, unusual behavioral changes (such as possible suicidal thoughts or actions), or new or worsening mental health symptoms, including anxiety, panic attacks, trouble sleeping, irritability, hostility, impulsivity, severe restlessness, or excessively rapid speech. Pay close attention to these symptoms, particularly when starting a new antidepressant or adjusting the dosage.

This medication may cause certain side effects, such as difficulty thinking clearly, sensations similar to feeling drunk, dizziness, nausea, vomiting, drowsiness, fatigue, or a decreased sense of touch. Usually, these effects are mild and temporary. However, if they persist or worsen, it is important to consult a healthcare professional. Serious side effects are uncommon but should be addressed immediately. These include increased nighttime urination, burning pain when urinating, or frequent and urgent urination.

Additionally, this medication can lead to a temporary increase in blood pressure, particularly within four hours of taking a dose. Blood pressure monitoring is advised before and after administration. Seek urgent medical attention if you experience severe side effects, such as chest pain, difficulty breathing, a sudden intense headache, changes in vision, seizures, or loss of consciousness.

Though rare, allergic reactions can occur. Immediate medical help is necessary if symptoms like rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing appear. This overview does not cover all possible side effects. If you notice any other unusual symptoms, contact your healthcare provider for guidance.