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The safety information provided below highlights critical warnings associated with the use of this medication. It is important to review these details and consult with your healthcare provider should you have any concerns.

• Liver Damage: Terbinafine, although rare, can lead to severe liver damage or failure, which may be life-threatening. Individuals with current or previous liver problems are at a heightened risk. It is essential to undergo blood tests both before starting and during treatment to monitor liver health. If you encounter unexplained stomach pain, nausea, vomiting, dark urine, pale stools, or yellowing of the skin or eyes, contact your healthcare provider immediately.

• Changes to Taste and Smell: Some individuals may experience alterations in taste and smell while taking terbinafine. Although these side effects often resolve on their own, they can persist or become permanent in rare instances. Contact your healthcare provider if you notice these changes, as discontinuation of the medication might be necessary.

• Depression: A decrease in mood has been observed in some patients using terbinafine. Should you experience unusual mood changes, sleep disturbances, or symptoms of depression, it is important to speak with your healthcare provider.

• Low White Blood Cell Levels: Terbinafine can occasionally lower white blood cell counts, increasing susceptibility to infections. This is particularly a risk for those with weakened immune systems or who are on the medication for more than six weeks. Regular blood tests may be required to monitor white blood cell levels, and if they fall too low, discontinuation of the medication might be advised.

• Serious Skin Reactions: In rare cases, terbinafine can cause severe, potentially life-threatening skin reactions, including painful rashes and blisters. Immediate medical attention is necessary if you develop a new or severe rash, blisters, flu-like symptoms, or sores in the mouth.

• Lupus Flare-Up: Terbinafine may trigger a lupus flare-up, although this is uncommon. Inform your healthcare provider if you have a history of lupus prior to starting the medication, so they can watch for signs of a flare-up.

• Clotting and Bleeding Problems: Rarely, terbinafine may interfere with blood clotting, posing serious health risks. Seek urgent medical care if you experience unusual fever, weakness, bruising, purple skin spots, or unexpected bleeding.

Contraindication:

• Terbinafine should not be used by individuals with long-term or active liver problems due to the serious health risks involved. Consult your healthcare provider if this applies to you.

Common side effects:

• Headache
• Rash
• Diarrhea
• Upset stomach

Less common but important to monitor:

• Changes in sense of taste
• Excessive gas
• Itching
• Hives
• Nausea

Serious side effects:

• Significant changes in vision
• Unexplained bleeding or bruising
• Signs of liver damage (persistent nausea, vomiting, severe abdominal pain, dark urine, pale stools, yellowing of the skin or eyes)
• Very serious allergic reaction (rash, blisters, fever, swollen lymph nodes, severe dizziness, breathing difficulties)

Interactions with high risk of serious adverse effects and should be avoided:

• Eliglustat

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amphetamine
• Aripiprazole
• Benzphetamine
• Brexpiprazole
• Clozapine
• Codeine
• Deutetrabenazine
• Dextroamphetamine
• Dihydrocodeine
• Donepezil
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Fluoxetine
• Lisdexamfetamine
• Methamphetamine
• Metoclopramide
• Metoprolol
• Nebivolol
• Pitolisant
• Risperidone
• Tramadol
• Valbenazine
• Vortioxetine

Interactions with low risk that usually do not require a change in therapy:

• Aripiprazole Lauroxil
• Cyclosporine
• Lofexidine
• Nortriptyline
• Warfarin