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This safety and warning information is crucial for the safe use of this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Severe Skin Reactions: On rare occasions, griseofulvin may cause severe skin reactions, such as Stevens-Johnson syndrome (SJS), which can be life-threatening. Immediate medical attention is necessary if you develop a new or worsening rash, especially if it is accompanied by fever, unexplained blisters, or sores in your mouth.

• Serious Liver Problems: There is a rare risk of life-threatening liver damage or liver failure associated with griseofulvin use, particularly for individuals with a history of liver issues. Regular blood tests may be required to monitor your liver function. Contact your healthcare provider immediately if you experience symptoms such as unexplained stomach pain, nausea, vomiting, dark urine, pale stools, or yellowing of the skin or eyes.

• Pregnancy Warning: Griseofulvin should not be used during pregnancy due to the risk of birth defects. Animal studies have shown potential harm, and you may be required to take a pregnancy test before starting this medication. Additionally, griseofulvin can reduce the effectiveness of hormonal birth control, so non-hormonal methods (such as condoms, diaphragms, or a copper IUD) are recommended. Discontinue use immediately and consult your healthcare provider if you become pregnant.

Contraindications: This medication should be avoided in the following conditions due to potential health risks. Consult your healthcare provider if any of these apply to you:

• Diagnosis of porphyria
• Liver failure
• Pregnancy

Following these guidelines will help ensure the safe and effective use of your medication.

Common side effects:

• headache
• nausea
• vomiting
• diarrhea
• stomach upset
• tiredness
• dizziness
• trouble sleeping
• rash
• hives

Less common but important to monitor:

• numbness or tingling in the hands and feet
• mental or mood changes such as confusion
• hearing changes
• oral thrush
• new vaginal yeast infection

Serious side effects:

• severe skin reactions with fever, sore throat, cough, painful blisters, and body aches
• liver complications such as persistent nausea, dark urine, stomach pain, and yellowing of the skin or eyes
• kidney problems, like changes in urine output
• severe allergic reaction with rash, itching or swelling, severe dizziness, or trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Phenobarbital
• Warfarin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Desogestrel
• Dienogest
• Drospirenone
• Estradiol
• EthinylEstradiol
• Ethynodiol
• Etonogestrel
• Gestodene
• Levonorgestrel
• Medroxyprogesterone
• Mestranol
• Nomegestrol
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Porfimer
• Segesterone
• Ulipristal