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The safety and warning information outlined below is crucial for ensuring the safe use of this medication. Please read carefully and discuss with your healthcare provider if you have any questions or concerns.

• Protein in Urine: Tiopronin (Thiola) may lead to kidney issues, resulting in increased protein levels in urine. This risk is particularly pronounced in children who consume more than 50 mg/kg of body weight per day. Regular urine tests will be conducted by your healthcare provider to monitor protein levels.

• Similarity to d-Penicillamine: Tiopronin (Thiola) shares a structural resemblance with d-penicillamine, a drug used for treating kidney stones, rheumatoid arthritis, and copper accumulation. If you have experienced side effects from d-penicillamine, your healthcare provider might recommend a reduced dose of tiopronin (Thiola).

• Contraindications: Do not use this medication if you have an allergy or sensitivity to tiopronin (Thiola). It is essential to inform your healthcare provider of any such conditions before starting this medication, as it may pose serious health risks.

When taking this medication, some individuals may experience common side effects such as nausea, diarrhea or soft stools, fatigue, and a rash. These effects are generally mild, but if they persist or worsen, you should consult your healthcare provider. Other common side effects include canker sores, joint pain, weakness, vomiting, protein in the urine, and fever. While these symptoms are typically not serious, it's important to monitor them and seek advice if needed.

In addition to the common side effects, there are other possible reactions that may occur, such as allergic reactions leading to fever, rash, joint pain, and swollen lymph nodes. You might also experience loss of appetite, chest pain, swelling, bruising, wrinkly skin, stomach pain, trouble with erections, cough, and itching. A low red blood cell count is also possible, though less common. If any of these effects arise, especially if severe, contact your healthcare provider.

It is crucial to be aware of rare but serious side effects, which require immediate medical attention. Severe allergic reactions may present as skin rash, itching, hives, and swelling of the face, lips, tongue, or throat. Signs of kidney injury, such as a decrease in urine output and swelling of the ankles, hands, or feet, should also be addressed urgently. Always stay informed about your body’s responses to new medications and seek medical help if you notice concerning symptoms.