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This document provides essential safety information and warnings about the use of Tiopronin (Thiola). It is crucial to understand these details to ensure safe administration, and it is recommended to discuss any concerns with your healthcare provider.

• Kidney Disorders and Protein in Urine: Tiopronin (Thiola) may cause kidney-related issues, resulting in elevated protein levels in the urine. This side effect is particularly likely in children consuming more than 50 mg/kg of body weight per day. Regular urine tests may be conducted by your healthcare provider to monitor this condition.

• Structural Similarities to d-Penicillamine: Tiopronin (Thiola) shares a structural similarity with d-penicillamine, a drug used to treat conditions like kidney stones, rheumatoid arthritis, and copper accumulation. Due to this similarity, if you have previously experienced side effects from d-penicillamine, your healthcare provider may opt for a reduced dose of Tiopronin (Thiola).

• Contraindications: Do not use Tiopronin (Thiola) if you have a known allergy or sensitivity to this medication. Doing so may result in serious health complications. Always consult your healthcare provider if you suspect any contraindications apply to you.

Please ensure to follow all medical advice and initiate regular discussions with your healthcare provider regarding any potential risks associated with Tiopronin (Thiola).

When taking this medication, you might experience some common side effects. Nausea, diarrhea or soft stools, and a decreased sense of taste or smell are among the most frequent. You may also notice canker sores, fatigue, rashes, joint pain, weakness, vomiting, and protein in your urine. These effects are often mild but should be discussed with your healthcare provider if they persist or worsen.

Be aware of other potential side effects, including loss of appetite, chest pain, swelling, bruising, wrinkly skin, stomach pain, trouble with erections, cough, and itching. While less common, these symptoms should still prompt a conversation with your healthcare provider, especially if they become severe.

Some side effects are rare but serious, and they require immediate medical attention. These include severe allergic reactions characterized by fever, rash, joint pain, swollen lymph nodes, or symptoms like skin rash, itching, hives, and swelling of the face, lips, tongue, or throat. Additionally, signs of kidney problems, such as a decrease in urine production or swelling of the ankles, hands, or feet, are critical and demand urgent care.

It is important to remain vigilant and report any unusual symptoms to your healthcare provider. This ensures that any side effects are managed appropriately and effectively.