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This document outlines crucial safety information and warnings related to the use of Trelegy Ellipta. Please read these details carefully and discuss any concerns with your healthcare provider.

• Not for Acute Respiratory Episodes: Trelegy Ellipta is not suitable for immediate relief of asthma or COPD attacks. In such cases, use a fast-acting rescue inhaler like albuterol.

• Risk of Oral Thrush: The steroid component, fluticasone, may lead to a fungal infection in the mouth known as thrush. To minimize this risk, rinse your mouth with water and spit after each inhalation. Consult your doctor if you experience symptoms like white patches, a cotton-like sensation, pain, or loss of taste in your mouth.

• Bronchospasm Warning: Trelegy Ellipta may occasionally cause bronchospasm, leading to breathing difficulties. Use your rescue inhaler and seek medical attention immediately if this occurs.

• Allergic Reactions: Be aware of potential allergic reactions, including severe facial swelling or anaphylaxis. Seek immediate medical help if you experience hives, rash, swelling, or breathing difficulties. Note: Individuals allergic to milk proteins should exercise caution.

• Increased Infection Risk: As a corticosteroid, Trelegy Ellipta can weaken the immune system, increasing infection risk. Inform your healthcare provider if you are being treated for a serious infection like tuberculosis.

• Hormonal Changes: Overuse of Trelegy Ellipta can affect stress hormone levels, potentially raising blood sugar or blood pressure. Use only as directed.

• Growth Delay in Children: Trelegy Ellipta is approved for adults only, as inhaled steroids may delay growth in children.

• Eye Health Concerns: Long-term use may increase the risk of eye problems such as glaucoma or cataracts. Consult your eye specialist if you have a history of these conditions or notice vision changes.

• Heart-Related Issues: Vilanterol in Trelegy Ellipta may affect heart rate and blood pressure. Regular monitoring is advised if you have existing heart conditions.

• Low Potassium Levels: Overuse can lead to decreased blood potassium, causing fatigue, weakness, or muscle cramps. Contact your doctor if these symptoms arise.

• Urination Difficulties: Umeclidinium can cause urinary retention, particularly in those with prostate issues. Notify your healthcare provider if you experience this.

• Contraindications: Do not use Trelegy Ellipta for sudden asthma or COPD attacks or if you have allergies to any of its active ingredients or milk proteins.

Always follow your healthcare provider's instructions and report any adverse reactions or inefficacy of the medication promptly.

When taking this medication, you may experience mild side effects as your body adjusts. Common symptoms can include a dry or irritated throat, hoarseness, coughing, headache, back pain, changes in taste, and diarrhea. Typically, these effects are temporary and should ease over time. However, if they persist or worsen, it is advisable to consult your healthcare provider for guidance.

In some cases, users have reported experiencing symptoms such as a common cold or sore throat, upper respiratory tract infections, bronchitis, sinus infections, and back pain. While these are generally manageable, if they become bothersome, seeking medical advice is recommended.

Though less common, there are more serious side effects that require immediate attention. These include severe wheezing or trouble breathing, chest pain, fast or irregular heartbeat, severe dizziness, fainting, eye pain or swelling, vision changes, and symptoms of a serious allergic reaction such as rash, swelling, or difficulty breathing. Additionally, seek urgent care if you experience cough, mouth and throat pain, thrush, pneumonia, stomach flu, flu, urinary tract infections, constipation, joint pain, or voice changes.

Monitoring your blood pressure is important, as this medication can increase it. Contact your healthcare provider if you notice elevated readings. While rare, any new or unusual symptoms should be reported to your healthcare provider to ensure your safety and wellbeing.