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This medication requires careful consideration of the following safety information before use. It is essential to discuss any concerns or questions with your healthcare provider.

• Cigarette Smoking and Heart Risks: Smoking while using combined oral contraceptives like Tri-Sprintec increases the likelihood of severe cardiovascular events, including strokes, heart attacks, and blood clots. This risk is significantly higher in women aged 35 and above who smoke. Consult your provider for alternative birth control options if you smoke.

• Blood Clots and Strokes: Tri-Sprintec may elevate the risk of blood clots, which can impact the lungs, legs, brain, or heart. Seek immediate medical assistance if symptoms of a blood clot appear. Those at higher risk include women over 35 who smoke, individuals over 40, those who have undergone recent surgery with prolonged immobility, and individuals with high blood pressure, obesity, high cholesterol, diabetes, or those using higher doses of estrogen.

• Irregular Bleeding: Initial use of Tri-Sprintec can lead to irregular bleeding or spotting, which may resolve over time. Continue taking the medication as directed, but consult your provider if bleeding persists. Missed periods should be reported to your provider, or a pregnancy test should be conducted.

• High Blood Pressure: This medication can increase blood pressure, particularly in older women or those using it long-term. Women with uncontrolled high blood pressure should avoid Tri-Sprintec. Regular monitoring of blood pressure is advised, and any significant changes should be discussed with your provider.

• Blood Sugar and Cholesterol Levels: Tri-Sprintec may heighten blood sugar and triglyceride levels, posing a greater risk for individuals with prediabetes or diabetes. Consultation with your provider is recommended if you have a history of high blood sugar or triglycerides.

• Cancer Risks: There is a potential increased risk of breast and cervical cancer with Tri-Sprintec use. Individuals with a personal or family history of these cancers should discuss the risks with their healthcare provider.

• Liver Problems: Avoid Tri-Sprintec if you have liver issues, including severe scarring, liver tumors, or viral infections. Discontinue use if signs of liver problems occur, such as jaundice or dark urine, and seek medical advice.

• Headaches and Migraines: New or worsening headaches should be reported to your provider, especially if they become severe or persistent.

• Depression: Any new or worsening symptoms of depression should be communicated to your healthcare provider. Severe cases may necessitate discontinuation of the medication.

Contraindications: Do not use Tri-Sprintec if you:

• Are over 35 and smoke.
• Have a history of blood clots, heart attacks, strokes, or certain heart conditions.
• Suffer from uncontrolled high blood pressure or diabetes with complications.
• Experience severe migraines with aura.
• Have liver problems, unexplained vaginal bleeding, or a history of breast cancer.
• Are taking certain hepatitis C medications.

Consult your healthcare provider if any of these conditions apply to you, as Tri-Sprintec may pose serious health risks.

When using this medication, some individuals may experience common side effects that are generally mild. These may include headaches or migraines, which occur in about 34% of users. Breast changes, such as tenderness or enlargement, are reported by 8% of users. Vaginal infections may affect 7% of individuals, while stomach pain is experienced by 6%. These side effects are typically not severe, but if they persist or worsen, it is advisable to consult a healthcare provider.

There are other side effects that have been noted, which include mood changes, vaginal discharge, and changes in weight. These are less common and usually not severe, but it's important to monitor them and seek advice if they become concerning.

Serious side effects are rare but require immediate medical attention due to their severity. These include heart attack symptoms such as chest pain, stomach discomfort, sweating, nausea, and dizziness. A stroke may present with sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, or difficulty walking. Deep vein thrombosis, indicated by leg cramp, swelling, pain, or muscle tightness, and pulmonary embolism, which may cause cough, chest pain, trouble breathing, or a racing heart, are also serious and require urgent care. If any of these symptoms occur, it is crucial to seek emergency medical help immediately.