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This document outlines critical safety information for Twyneo (tretinoin / benzoyl peroxide), highlighting potential risks, necessary precautions, and special instructions. Please read carefully and consult your healthcare provider with any concerns.

• Severe Allergic Reactions: Inform your healthcare provider if you have a history of allergic reactions to tretinoin or benzoyl peroxide. Though rare, severe allergic reactions can occur. Symptoms may include hives, itching, confusion, difficulty breathing, throat tightness, and loss of consciousness. If you experience these symptoms, discontinue use immediately and contact your healthcare provider.

• Skin Irritation: Common side effects include stinging, burning, dryness, and redness, particularly in the initial two weeks of treatment. These symptoms often improve over time. Use a hydrating moisturizer to alleviate dryness and avoid applying the medication on open wounds or sunburned areas to prevent further irritation. Severe side effects may necessitate reduced usage or discontinuation; consult your healthcare provider if necessary. Individuals with sensitive skin should discuss the suitability of this product with their healthcare provider.

• Sun Sensitivity: This medication may increase your skin's sensitivity to sunlight, heightening the risk of sunburn. Limit sun exposure, seek shade, and wear sunscreen with an SPF of at least 30. Protective clothing, such as hats and long sleeves, is also recommended. Avoid artificial sunlamps and tanning beds to prevent additional skin irritation.

• Contraindications: Do not use Twyneo if you have had a severe allergic reaction to tretinoin or benzoyl peroxide in the past, as it may pose serious health risks.

For any questions or clarifications, please contact your healthcare provider.

When using this medication, some individuals may experience mild side effects such as redness, dryness, itching, peeling, or mild burning at the application site. These are generally manageable, and using a moisturizer may help alleviate them. However, if these symptoms persist or worsen, it's important to consult with a healthcare provider.

In rare cases, more serious side effects can occur, such as blistering, crusting, or severe burning and swelling of the skin. Discoloration of the skin is also a potential concern. If any of these severe reactions develop, it is crucial to seek medical advice promptly.

A very serious allergic reaction to this medication, known as anaphylaxis, is rare but requires immediate medical attention. Symptoms of anaphylaxis include rash, severe itching or swelling, particularly of the face, tongue, or throat, severe dizziness, and difficulty breathing. If you experience these symptoms, get medical help right away.

If you notice any other unusual effects while using this medication, contacting your healthcare provider for guidance is advisable. Always be attentive to any changes and prioritize your safety by addressing concerns with a medical professional.