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The use of Kyzatrex (testosterone undecanoate) comes with important safety considerations and warnings. It is crucial to understand these risks and consult with your healthcare provider to ensure safe and effective use of this medication. Please review the following information carefully:

• High Blood Pressure and Cardiovascular Risks: This medication can increase blood pressure, which may elevate the risk of severe heart-related issues such as heart attacks, strokes, or sudden cardiac death. Those with pre-existing heart conditions or risk factors should be particularly cautious. Regular monitoring of blood pressure is advised, and medication adjustments may be necessary if hypertension develops.

• Elevated Red Blood Cell Count: Kyzatrex can lead to an increase in red blood cell count, raising the possibility of blood clots, strokes, and heart attacks. Routine blood tests every three months are recommended to monitor red blood cell levels. Seek immediate medical attention if you experience symptoms like chest pain or difficulty breathing.

• Risk of Blood Clots: The medication may cause dangerous blood clots in the legs or lungs, with symptoms such as leg pain, swelling, or chest pain. Prompt medical intervention is required if these symptoms occur.

• Misuse and Dependency Potential: As a controlled substance, Kyzatrex has a risk of misuse, dependency, and addiction, especially at higher doses or when combined with other testosterone products. Misuse can lead to severe health issues, including heart and mental health problems. Be aware of withdrawal symptoms such as depression and insomnia if the medication is reduced or stopped.

• Prostate Health Concerns: This medication can exacerbate symptoms of an enlarged prostate or benign prostatic hyperplasia (BPH) and may pose a risk for prostate cancer. Inform your provider of any urinary changes.

• Liver Health Considerations: While Kyzatrex itself isn't known to directly cause liver problems, prolonged use of other testosterone forms can lead to significant liver issues. Report any symptoms such as stomach pain or jaundice to your healthcare provider.

• Fertility Impact: Higher doses of Kyzatrex can reduce sperm production, potentially affecting fertility. Discuss any family planning concerns with your healthcare provider.

• Fluid Retention and Edema: The medication may cause fluid retention, leading to swelling in the limbs. This is particularly concerning for individuals with heart, liver, or kidney conditions, especially if taking medications like corticosteroids.

• Sleep Apnea Concerns: Kyzatrex can worsen sleep apnea symptoms, particularly in those with obesity or lung conditions. Discuss any changes in sleep patterns with your provider.

• Hypercalcemia: The medication can increase calcium levels, especially in cancer patients, causing muscle weakness and kidney issues. Regular calcium level checks may be necessary during treatment.

Contraindications:

• This medication should not be used by individuals with breast or prostate cancer, those who are pregnant, or those with low testosterone levels due to non-genetic causes. Always consult your healthcare provider to determine if Kyzatrex is suitable for you.

When taking this medication, you may experience some common side effects such as nausea, headache, vomiting, oily skin, hair loss, acne, and changes in skin color or sexual interest. While these effects are usually mild, if they continue or worsen, it’s important to talk to your healthcare provider. Less commonly, individuals may experience symptoms like increased blood pressure, diarrhea, constipation, joint pain, or swelling in the limbs. Again, consult your healthcare provider if these occur.

Serious side effects, although rare, demand immediate medical attention. These include symptoms of heart attack such as chest pain, cold sweats, and left arm pain; signs of a stroke including face drooping and trouble speaking; and indications of a blood clot like swelling or pain in the legs. Liver damage is another severe risk, with symptoms like persistent stomach pain, yellowing skin or eyes, and dark urine. If you notice any of these, seek medical help promptly.

Other serious concerns include mental or mood changes, sleep disturbances, swelling of limbs, unusual tiredness, changes in heartbeat, and difficulty urinating. In rare cases, prolonged or painful erections lasting over four hours can occur, requiring immediate healthcare intervention to prevent long-term damage. Additionally, be alert for allergic reactions such as rash, severe dizziness, or trouble breathing, and seek help immediately if they occur. Always communicate with your healthcare provider about any side effects you experience.