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Vasculera is a prescription medical food designed for the nutritional management of chronic venous insufficiency (CVI). While it is generally safe for daily use under a physician's supervision, certain precautions are necessary to ensure its appropriate use.

Individuals with known allergies to Vasculera, povidone, cellulose, or corn products should avoid using this product. If you experience signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek emergency medical attention immediately.

Before starting Vasculera, inform your healthcare provider about all your medical conditions and any other medications, vitamins, or herbal supplements you are currently taking. This information is crucial to prevent potential complications and to ensure that Vasculera is suitable for your specific health needs.

It may take up to eight weeks to notice improvements in your symptoms. Continue using the medication as directed, and consult your doctor if your symptoms do not improve after four weeks of treatment. If your symptoms worsen at any time, contact your healthcare provider promptly.

Always follow the directions provided on your prescription label and read all accompanying medication guides or instruction sheets. Your doctor may adjust your dose as needed, so use the medicine exactly as directed. Store Vasculera at room temperature, away from moisture, heat, and light, to maintain its effectiveness.

By adhering to these guidelines and maintaining open communication with your healthcare provider, you can use Vasculera safely and effectively as part of your CVI management plan.

When considering Vasculera (diosmiplex) for managing chronic venous insufficiency, it's important to be aware of potential interactions with other medications. While Vasculera is generally well-tolerated, certain drugs may interact with it, leading to increased side effects or altered effectiveness.

Medications with Noted Interactions:

• Chlorzoxazone (Parafon Forte): An interaction has been described between Vasculera and chlorzoxazone, a muscle relaxant.

• Diclofenac (Voltaren): Vasculera may interact with diclofenac, a nonsteroidal anti-inflammatory drug (NSAID).

• Metronidazole (Flagyl): An interaction has been noted between Vasculera and metronidazole, an antibiotic.

These interactions were identified through pharmacokinetic studies in healthy individuals, but they have not been reported in clinical practice. If you experience any unusual symptoms while taking Vasculera with these medications, inform your doctor promptly.

Other Medications to Consider:

Vasculera may also interact with the following medications:

• Mavorixafor: Co-administration with Vasculera may increase mavorixafor's plasma concentrations, potentially leading to side effects such as QT interval prolongation.

• Rimegepant: Taking Vasculera with rimegepant may elevate rimegepant levels, increasing the risk of side effects like nausea and abdominal discomfort.

• Repotrectinib: Concurrent use with Vasculera may raise repotrectinib levels, potentially intensifying side effects such as dizziness and liver injury.

Recommendations:

• Consult Your Healthcare Provider: Before starting Vasculera, discuss all current medications, including over-the-counter drugs and supplements, with your doctor to assess potential interactions.

• Monitor for Side Effects: Be vigilant for any new or worsening symptoms when combining Vasculera with other medications and report them to your healthcare provider.

• Follow Medical Advice: Do not discontinue or adjust the dosage of any prescribed medication without consulting your doctor.

By staying informed and maintaining open communication with your healthcare provider, you can safely incorporate Vasculera into your treatment regimen while minimizing the risk of adverse interactions.