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This medication requires careful attention to safety warnings and usage guidelines. Please review the following information and discuss any concerns with your healthcare provider:

• Suicidal Thoughts or Mood Changes: Bupropion may increase the risk of suicidal thoughts or behavior, particularly in individuals under 24 years old. Alcohol consumption can exacerbate these effects. Be vigilant for unusual mood changes, worsening depression, agitation, or hostility, especially at the start of treatment or with dosage adjustments. If these occur, discontinue use and contact your healthcare provider immediately. This risk is higher for those under 24, with a history of depression, mental health conditions, or alcohol use.

• Mental Health Concerns: Although Wellbutrin XL, Wellbutrin SR, bupropion HCl, and Forfivo XL are not FDA-approved for smoking cessation, they contain the same active ingredient as Zyban. Serious mental health side effects, such as depression, hallucinations, psychosis, paranoia, delusions, aggression, and suicidal thoughts, have been reported. Monitor for symptoms like depressed mood or behavioral changes. Stop the medication and consult your provider if these symptoms arise. Risks increase with a history of depression or mental health issues, or when experiencing nicotine withdrawal symptoms.

• Seizure Risk: The use of bupropion can heighten the likelihood of seizures, particularly if taken in excess of the recommended dose. Follow your provider’s prescription precisely. Avoid bupropion if you have a history of seizures or conditions that increase seizure risk, such as head trauma or eating disorders, or if you have recently stopped using alcohol or seizure-inducing medications. Discontinue use and inform your provider promptly if a seizure occurs. Higher risk is associated with excessive dosage, seizure or eating disorder history, recent cessation of certain substances, or concurrent use of medications that may cause seizures.

• High Blood Pressure: Bupropion may lead to elevated blood pressure, especially in those predisposed to this condition. Regularly monitor your blood pressure and report any significant changes or symptoms like dizziness to your healthcare provider. Risk factors include a history of high blood pressure and concurrent use of medications that can increase blood pressure, such as MAOIs and nicotine replacement therapies.

• Mania Risk: Individuals with bipolar disorder taking bupropion without additional medication may experience mania. Symptoms include heightened energy, sleep disturbances, excessive happiness or irritability, and overactivity. This is more probable if you or a family member has a history of bipolar disorder. Seek immediate medical advice if unusual behavior changes occur.

Contraindications:

Avoid using this medication if you have:

• A history of seizures.
• A history of eating disorders, such as bulimia or anorexia.
• Recently stopped consuming alcohol or taking benzodiazepines, barbiturates, or antiepileptic medications.
• Used monoamine oxidase inhibitors (MAOIs) in the past 14 days or plan to use them in the next 14 days.
• Are undergoing treatment with linezolid or intravenous methylene blue.

Consult with your healthcare provider if any of these conditions apply to you, as the medication could pose serious health risks.

When taking this medication, some individuals may experience common side effects which are generally mild. These include headaches, dry mouth, nausea, trouble sleeping, dizziness, sore throat, constipation, and restlessness. If these side effects persist or cause discomfort, discussing them with your healthcare provider is advisable.

There are also other side effects that have been reported, which should be monitored closely. These include stomach pain, anxiety, confusion, tremors, a fast heartbeat, sweating, ringing in the ears, blurred vision, muscle pain, loss of appetite, increased urinary frequency, and rash. While these are less common, they should be addressed with a healthcare provider if they occur, particularly if they are severe.

In rare instances, more serious side effects can occur, requiring immediate medical attention. These include suicidal thoughts and changes in mood or behavior, severe allergic reactions such as itchy skin, hives, swelling, shortness of breath, or chest pain. Severe skin reactions like painful rashes, fluid-filled blisters, fever, sore throat, or peeling skin also warrant urgent care. Additional serious effects include seizures, manic episodes characterized by extreme mood changes and sleep issues, and vision problems such as eye pain or changes in vision. It is crucial to seek medical help promptly if any of these severe reactions arise.