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When considering the use of Zurzuvae (zuranolone), it's crucial to be aware of the following safety information and warnings to ensure its safe and effective use:

• Impaired Abilities: This medication can significantly impair your alertness and ability to drive or perform tasks requiring focus. For at least 12 hours after taking a dose, do not drive, operate machinery, or engage in activities that need your full attention. Be mindful that you might not accurately assess your ability to perform such tasks safely.

• Drowsiness and Dizziness: You may experience dizziness, drowsiness, or confusion, increasing the risk of falls and injury, especially when combined with alcohol or other sedative substances such as benzodiazepines, opioids, or certain antidepressants. Some medicines can also interfere with how Zurzuvae is broken down in your body, potentially leading to heightened side effects. If severe drowsiness or dizziness occurs, contact your healthcare provider. They may adjust your dose or suggest alternative treatments.

• Mental Health Risks: As an antidepressant, Zurzuvae may exacerbate depression and increase suicidal thoughts or behaviors, particularly in individuals aged 24 or younger. If you or those around you notice signs of suicidal thoughts, anxiety, panic attacks, irritability, or restlessness, seek medical attention immediately. Your doctor may decide to discontinue the medication.

• Pregnancy Concerns: Animal studies suggest that Zurzuvae could harm unborn babies. If you are pregnant or could become pregnant, use effective contraception during treatment and for one week after the last dose to prevent pregnancy.

• Substance Interactions: Avoid alcohol and discuss with your doctor if you are using marijuana (cannabis) or any other substances that may interact with Zurzuvae.

In the event of an overdose, immediate medical assistance is required. Always follow your healthcare provider's guidance and report any side effects or concerns promptly.

When taking this medication, you might experience some mild side effects, such as drowsiness, dizziness, diarrhea, or a feeling of tiredness. These effects are usually not severe, but if they persist or worsen, it's advisable to consult a healthcare provider. Some individuals also report extreme sleepiness, lack of energy, or urinary tract infections. While these are common, they are often mild and temporary.

There are other side effects that, although less common, can occur. These include memory problems, stomach pain, tremors, numbness or a reduced sensitivity to touch, muscle twitching, muscle pain, and anxiety. If any of these symptoms arise, especially if they become bothersome, reaching out to a healthcare professional is recommended.

It is crucial to be aware of serious side effects that, although rare, require immediate medical attention. These include confusion, trouble walking, suicidal thoughts or behavior, and severe allergic reactions characterized by rash, itching, swelling, severe dizziness, or difficulty breathing. If you experience any signs of worsening depression, unusual behavior changes, or other significant mental health changes, it is important to seek help promptly. Always monitor your symptoms closely, particularly when starting or adjusting the dosage of the medication.