Abiraterone

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abiraterone

Abiraterone, marketed under the brand names Zytiga and Yonsa, is a medication used to treat specific types of prostate cancer. This drug is particularly effective against cancers that require testosterone to grow and can also target those that continue to grow despite low testosterone levels. Abiraterone belongs to a class of drugs known as anti-androgens and works by blocking the production of testosterone, a hormone that aids in the growth and spread of prostate cancer. The medication is taken orally once a day and is typically combined with a steroid, which is taken once or twice daily. In some cases, an additional medication that targets gonadotropin-releasing hormone (GnRH) may be necessary unless a surgical procedure to remove both testicles (bilateral orchiectomy) has been performed. Common side effects of Abiraterone include high blood pressure and swelling due to fluid retention. Abiraterone should not be administered to women or children. It is available as lower-cost generics under the brand name Zytiga, while Yonsa is not yet available as a generic. Always consult with a healthcare professional before starting any treatment to ensure it is safe and appropriate for your condition.
Our Zytiga coupons are free to use. You can print the coupon, email it to yourself, or receive the Zytiga coupon via text message. To get your free discount, show the pharmacist your Zytiga savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Zytiga prices will update based on your prescription needs. Above our Zytiga coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Zytiga savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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250MG, Abiraterone (30 Tablets)

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$34.71

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$55.30

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Zytiga dosage forms

The average cost for 30 Tablets of Zytiga (abiraterone) at 250MG is $37.25 with a free coupon. This is 1.35% off the average retail price of $2762.7
DosageQuantityPrice fromPer unit
250MG30 Tablets$37.25$1.24
500MG30 Tablets$533.72$17.79

Zytiga Warnings

Please review the following safety and warning information regarding the use of Abiraterone (Zytiga) carefully. It is important to discuss any concerns with your healthcare provider to ensure safe use of this medication.

  • Fluid Retention and Heart Issues: Abiraterone (Zytiga) can alter hormone levels, potentially causing fluid retention, heart rhythm changes, and low potassium levels. These effects can be particularly severe in individuals with pre-existing heart conditions, such as heart failure or a history of heart attack. Regular monitoring of blood pressure and potassium levels through lab tests is essential. A steroid medication will be prescribed alongside Abiraterone to mitigate these risks. Notify your healthcare provider immediately if you experience symptoms like dizziness, rapid heartbeat, lightheadedness, confusion, or swelling in your limbs.

  • Adrenal Insufficiency: The use of Abiraterone may lead to reduced production of stress hormones by the body. To counteract this, a steroid such as prednisone or methylprednisolone will be prescribed. Abrupt cessation of steroid use or excessive stress can exacerbate this condition. Report any signs of adrenal insufficiency, such as weight loss, fatigue, confusion, or abdominal pain, to your provider promptly.

  • Liver Toxicity: Abiraterone can cause liver damage, particularly within the first three months of treatment. Liver issues may not always present with symptoms, so frequent blood tests will be conducted initially to assess liver health. Contact your provider immediately if you notice symptoms such as fatigue, appetite loss, nausea, vomiting, dark urine, abdominal pain, or jaundice.

  • Pregnancy Risks: Abiraterone may harm an unborn child or increase the risk of miscarriage, as indicated by animal studies. Use effective birth control methods, such as condoms, if your partner is capable of becoming pregnant while you are on this medication and for three weeks following the last dose. Additionally, your partner should avoid touching the tablets to minimize exposure. Inform your healthcare provider immediately if your partner becomes pregnant during this period.

  • Hypoglycemia: Patients with diabetes taking medications like pioglitazone (Actos) or repaglinide may experience low blood sugar levels when using Abiraterone. Blood sugar levels should be closely monitored, and adjustments to diabetes medications may be necessary. Report symptoms of low blood sugar, such as sweating, tremors, rapid heartbeat, confusion, or dizziness, to your healthcare provider.

If you have any questions or need further information, please do not hesitate to reach out to your healthcare provider.

Zytiga Side Effects

When taking this medication, you might experience some common side effects that are generally mild. These can include tiredness, headaches, hot flushes, joint pain, muscle discomfort, and swelling due to fluid retention. Other possible symptoms include constipation, diarrhea, heartburn, and cold-like symptoms such as a runny nose or sore throat. While these effects typically subside on their own, if they persist or worsen, it’s advisable to consult a healthcare provider.

This medication may also cause an increase in blood pressure, sometimes accompanied by dizziness or headaches. Regular monitoring of your blood pressure is recommended, and you should consult your healthcare provider if you notice elevated readings. Other potential side effects include trouble sleeping, fever, and groin pain. Some individuals may experience increased urination, particularly at night, or symptoms of a urinary tract infection. If you notice a rash or changes in heart rhythm, such as chest pain or an irregular heartbeat, seek medical advice.

Though rare, serious side effects require immediate medical attention. These include symptoms of liver damage, such as persistent nausea, vomiting, abdominal pain, loss of appetite, or yellowing of the skin or eyes. Additionally, signs of dangerously low stress hormone levels, like a fast heartbeat, confusion, and muscle weakness, should not be ignored. A serious allergic reaction, while uncommon, necessitates urgent care if you experience rash, swelling, severe dizziness, or difficulty breathing. Always report any new or worsening symptoms to your healthcare provider for further guidance.

Zytiga Interactions

When taking Abiraterone (Zytiga), be aware that it can interact with various medications and supplements. It is important to inform your healthcare provider about all the drugs and supplements you use, including prescriptions, over-the-counter medications, vitamins, and herbal products. Some drugs, such as Dasabuvir, Eliglustat, and Selexipag, should generally not be used with Abiraterone, as your doctor might need to adjust your treatment plan if you are taking these. Additionally, there are medications like Carbamazepine, Phenytoin, St. John's Wort, and Radium Ra 223 Dichloride that typically are not recommended to be used with Abiraterone but might be necessary in some situations. In such cases, your doctor may alter the dosage or frequency of usage. Certain other medications, including Dextromethorphan and Repaglinide, may increase the risk of side effects when used with Abiraterone, but they might still be part of your treatment if deemed necessary. Always consult with your healthcare provider for guidance on managing these interactions.
Zytiga FAQs
Is Zytiga a chemotherapy drug?

Zytiga is not classified as a chemotherapy drug. It is a type of hormone therapy used to treat prostate cancer by decreasing the production of androgens, which can fuel the growth of prostate cancer cells.

Zytiga, also known as abiraterone acetate, may cause several side effects. Common side effects include fatigue, joint swelling or pain, hot flashes, diarrhea, vomiting, cough, high blood pressure, and low blood potassium levels. More serious side effects can include liver function changes, adrenal problems, and heart issues such as irregular heartbeats or heart failure. It is important for patients to discuss any side effects they experience with their healthcare provider.

Zytiga is given with prednisone to help manage and mitigate the side effects associated with Zytiga, particularly the risk of increased mineralocorticoid levels, which can lead to issues such as hypertension, hypokalemia, and fluid retention. Prednisone helps to counteract these effects by providing glucocorticoid activity, which helps maintain a balance in the body's steroid levels.

Prednisone is often prescribed alongside abiraterone to help manage side effects. Abiraterone can cause an increase in mineralocorticoid levels, leading to side effects such as high blood pressure, low potassium levels, and fluid retention. Prednisone helps mitigate these effects by providing glucocorticoid activity, which helps balance the body's steroid levels and reduce the risk of these side effects.

To determine if Zytiga is working, a healthcare provider will typically monitor the patient's prostate-specific antigen (PSA) levels, as a decrease in PSA can indicate that the medication is effective. Additionally, the provider may assess the patient's symptoms, conduct physical examinations, and use imaging studies such as CT scans or MRIs to evaluate the progression of the cancer. Regular follow-up appointments are essential to assess the treatment's effectiveness and make any necessary adjustments.