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Please review the following safety and warning information regarding the use of Abiraterone (Zytiga) carefully. It is important to discuss any concerns with your healthcare provider to ensure safe use of this medication.

• Fluid Retention and Heart Issues: Abiraterone (Zytiga) can alter hormone levels, potentially causing fluid retention, heart rhythm changes, and low potassium levels. These effects can be particularly severe in individuals with pre-existing heart conditions, such as heart failure or a history of heart attack. Regular monitoring of blood pressure and potassium levels through lab tests is essential. A steroid medication will be prescribed alongside Abiraterone to mitigate these risks. Notify your healthcare provider immediately if you experience symptoms like dizziness, rapid heartbeat, lightheadedness, confusion, or swelling in your limbs.

• Adrenal Insufficiency: The use of Abiraterone may lead to reduced production of stress hormones by the body. To counteract this, a steroid such as prednisone or methylprednisolone will be prescribed. Abrupt cessation of steroid use or excessive stress can exacerbate this condition. Report any signs of adrenal insufficiency, such as weight loss, fatigue, confusion, or abdominal pain, to your provider promptly.

• Liver Toxicity: Abiraterone can cause liver damage, particularly within the first three months of treatment. Liver issues may not always present with symptoms, so frequent blood tests will be conducted initially to assess liver health. Contact your provider immediately if you notice symptoms such as fatigue, appetite loss, nausea, vomiting, dark urine, abdominal pain, or jaundice.

• Pregnancy Risks: Abiraterone may harm an unborn child or increase the risk of miscarriage, as indicated by animal studies. Use effective birth control methods, such as condoms, if your partner is capable of becoming pregnant while you are on this medication and for three weeks following the last dose. Additionally, your partner should avoid touching the tablets to minimize exposure. Inform your healthcare provider immediately if your partner becomes pregnant during this period.

• Hypoglycemia: Patients with diabetes taking medications like pioglitazone (Actos) or repaglinide may experience low blood sugar levels when using Abiraterone. Blood sugar levels should be closely monitored, and adjustments to diabetes medications may be necessary. Report symptoms of low blood sugar, such as sweating, tremors, rapid heartbeat, confusion, or dizziness, to your healthcare provider.

If you have any questions or need further information, please do not hesitate to reach out to your healthcare provider.

When taking this medication, you might experience some common side effects that are generally mild. These can include tiredness, headaches, hot flushes, joint pain, muscle discomfort, and swelling due to fluid retention. Other possible symptoms include constipation, diarrhea, heartburn, and cold-like symptoms such as a runny nose or sore throat. While these effects typically subside on their own, if they persist or worsen, it’s advisable to consult a healthcare provider.

This medication may also cause an increase in blood pressure, sometimes accompanied by dizziness or headaches. Regular monitoring of your blood pressure is recommended, and you should consult your healthcare provider if you notice elevated readings. Other potential side effects include trouble sleeping, fever, and groin pain. Some individuals may experience increased urination, particularly at night, or symptoms of a urinary tract infection. If you notice a rash or changes in heart rhythm, such as chest pain or an irregular heartbeat, seek medical advice.

Though rare, serious side effects require immediate medical attention. These include symptoms of liver damage, such as persistent nausea, vomiting, abdominal pain, loss of appetite, or yellowing of the skin or eyes. Additionally, signs of dangerously low stress hormone levels, like a fast heartbeat, confusion, and muscle weakness, should not be ignored. A serious allergic reaction, while uncommon, necessitates urgent care if you experience rash, swelling, severe dizziness, or difficulty breathing. Always report any new or worsening symptoms to your healthcare provider for further guidance.