2-deoxy-d-glucose

Drug Details

2-Deoxy-D-glucose (2-DG) is a synthetic compound structurally similar to glucose, differing by the absence of a hydroxyl group at the second carbon position. This slight modification allows 2-DG to enter cells using the same transport mechanisms as glucose. Once inside, it is phosphorylated to 2-DG-6-phosphate but cannot proceed further in the glycolytic pathway, leading to an accumulation that disrupts energy production. This property has been explored in cancer therapy, as many cancer cells rely heavily on glycolysis for energy, a phenomenon known as the Warburg effect. By inhibiting glycolysis, 2-DG can impede cancer cell growth and survival. Additionally, 2-DG has been investigated for its potential in treating viral infections, including COVID-19, by interfering with viral replication processes. Its ability to target energy metabolism makes 2-DG a molecule of interest in both diagnostic imaging and therapeutic applications.