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Here are crucial safety warnings and precautions related to the use of phentermine (Adipex-P), a medication often prescribed for weight loss. It's important to carefully consider these points and consult your healthcare provider with any questions or concerns.

• Avoid Combination with Other Weight Loss Medications: The safety of using phentermine (Adipex-P) alongside other weight loss drugs, including over-the-counter options, is not well-established. Always speak with your primary care provider before combining it with any other weight loss medication.

• Tolerance Development: Phentermine (Adipex-P) may become less effective over time, a condition known as tolerance. Increasing the dosage is unsafe due to the potential for severe side effects. If you notice a return of appetite or weight gain, communicate with your primary care provider for alternative treatment options.

• Misuse and Dependence Risk: There is a potential for misuse and dependency, akin to other stimulants. To mitigate this, prescriptions are typically limited in quantity and duration. Follow the exact prescription and discuss long-term weight management strategies with your care team.

• Concentration and Coordination Impairment: This medication may impair your ability to concentrate or coordinate movements, potentially making activities like driving hazardous. If you experience dizziness or other related side effects, inform your healthcare provider promptly.

• Cardiopulmonary Concerns: Although rare, there have been past instances of serious pulmonary and heart valve issues with similar medications. Be vigilant for symptoms like chest pain or shortness of breath and report them immediately to your provider.

• Hypertension Risk: Inform your healthcare provider if you have high blood pressure before starting phentermine (Adipex-P). Regular monitoring may be necessary, and adjustments to your treatment may be required if blood pressure levels change.

• Hypoglycemia in Diabetics: For individuals with diabetes taking blood sugar-lowering medications, there is a heightened risk of hypoglycemia. Changes to your diabetes management plan may be necessary upon starting this medication.

Contraindications: Do not use phentermine (Adipex-P) if you have any of the following conditions, as it may pose serious health risks:

• Heart issues such as stroke, irregular heartbeat, or uncontrolled high blood pressure.
• Overactive thyroid or glaucoma.
• Agitation or distress.
• History of substance use disorder.
• Pregnancy or breastfeeding.
• Recent use of monoamine oxidase inhibitors (MAOIs).
• Severe allergy to amphetamine-containing products.

In the event of an overdose, seek emergency medical attention immediately. Always adhere to the prescribed dosage and consult your healthcare provider with any concerns about your treatment.

Common side effects:

• Dizziness
• Dry mouth
• Headache
• Tremor
• Constipation
• Diarrhea
• Difficulty sleeping
• Irritability

Less common but important to monitor:

• Nausea
• Vomiting
• Restlessness
• Changes in sexual function or interest
• Increase in blood pressure

Serious side effects:

• Fast or irregular heartbeat
• Severe headache
• Trouble speaking
• Seizures
• Weakness on one side of the body
• Vision changes
• Severe heart or lung problems
• Chest pain
• Difficulty breathing
• Swelling of the legs or ankles
• Decreased ability to exercise
• Severe allergic reactions

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)
• Furazolidone
• Iproniazid
• Sibutramine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• High blood pressure medications (guanethidine, Methyldopa)
• Phenothiazines (Prochlorperazine, Chlorpromazine)
• Other stimulants (amphetamines, Methylphenidate, cocaine, MDMA)
• Substances that cause drowsiness (opioid pain or cough medicines, alcohol, marijuana, sleep or anxiety drugs, muscle relaxants, antihistamines)
• Iobenguane I 131

Interactions with low risk that usually do not require a change in therapy:

• Caffeine