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This document outlines important safety information and precautions for the use of acetaminophen. It is essential to carefully consider these warnings to ensure safe usage of the medication.

• Liver Damage: Excessive intake of acetaminophen can lead to severe, potentially fatal liver damage. The maximum recommended dosage for adults is 4,000 mg per day, though your healthcare provider may advise a lower dosage based on your individual risk for liver problems. Children should have their dosage determined by a healthcare professional. Individuals with existing liver conditions should consult a doctor before using acetaminophen, as it can exacerbate liver damage.

• Overdose Risk: Acetaminophen is a common ingredient in many prescription and over-the-counter medications. Using multiple products containing acetaminophen can increase the risk of an accidental overdose, which can result in serious liver damage. Always check medication labels for acetaminophen content and maintain awareness of your total daily intake. In case of overdose, seek immediate medical attention or contact a Poison Control Center at 1-800-222-1222.

• Alcohol Interaction: Consuming three or more alcoholic beverages daily while taking acetaminophen increases the risk of liver damage. It is advisable to limit or avoid alcohol consumption when using this medication.

• Allergic Reactions: Though rare, acetaminophen can cause severe skin reactions, such as rashes, blistering, skin reddening, or peeling. Discontinue use and seek medical attention if any skin changes occur.

• Special Populations: Pregnant individuals, children, and those with pre-existing liver conditions should consult a healthcare provider before using acetaminophen to ensure safe use.

This information serves as a guide for the safe usage of acetaminophen and highlights the importance of consulting with a healthcare professional for personalized advice.

Common side effects:

• Nausea
• Headaches

Serious side effects:

• Allergic reactions (hives, rashes, skin blisters, peeling skin, swelling of the lips or tongue, difficulty breathing)
• Potential signs of liver damage (swelling of the stomach, yellowing of the skin or eyes, confusion, dark or brown urine)

Interactions with high risk of serious adverse effects and should be avoided:

• Imatinib
• Isoniazid
• Pixantrone
• Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acenocoumarol
• Carbamazepine
• Fosphenytoin
• Lixisenatide
• Phenytoin
• Warfarin
• Zidovudine

Interactions with low risk that usually do not require a change in therapy:

• Ketoconazole
• Levoketoconazole