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Zidovudine can lead to significant blood disorders, such as reduced red blood cells (anemia) and white blood cells (neutropenia). These conditions are particularly prevalent in individuals with advanced HIV (AIDS). Blood disorders may necessitate blood transfusions or discontinuation of the medication. Regular blood tests, as arranged by your doctor, are essential for monitoring. Ensure you attend all scheduled medical appointments. Seek immediate medical attention if you experience symptoms of anemia, including unusual fatigue, difficulty breathing, weakness, bluish nails or lips, pale skin, or a rapid heartbeat. A reduction in white blood cells can increase the risk of severe, possibly fatal infections. Promptly consult a healthcare professional if you notice symptoms of infection, such as a persistent cough, fever, chills, breathing difficulties, or a sore throat.

Additionally, zidovudine may cause muscle-related issues (myopathy). Immediate medical assistance is necessary if you encounter signs of myopathy, including muscle wasting, weakness, pain, tenderness, or unexplained weight loss.

In rare cases, zidovudine has been associated with severe, potentially fatal liver issues and a specific metabolic disorder known as lactic acidosis. Seek urgent medical care if you experience signs of liver troubles, such as persistent nausea, abdominal pain, dark urine, or yellowing of the eyes or skin, or symptoms of lactic acidosis, including rapid breathing, drowsiness, or muscle aches. These serious side effects are more commonly observed in women and obese individuals.

While taking this medication, you might experience some mild side effects such as headache, nausea, vomiting, difficulty sleeping, or a reduced appetite. These are common and often manageable. However, if they persist or worsen, it’s important to consult your healthcare provider.

Strengthening your immune system can sometimes cause dormant infections to become active, leading to recurring symptoms. Additionally, an overactive immune response can occur at any time, whether shortly after starting treatment or months later. Serious symptoms to watch for include unexplained weight loss, persistent fatigue, severe headaches, muscle or joint pain, numbness, vision changes, fever, swollen lymph nodes, breathing difficulties, and signs of infection. If you experience any of these, seek medical attention promptly.

Be alert for mental health changes like depression or anxiety, easy bruising or bleeding, and changes in skin or nail color. These could indicate more serious side effects that require immediate medical advice. Seizures are a very serious condition and warrant urgent medical help.

A rare but serious side effect is the loss of body fat in areas such as the face, arms, legs, and buttocks, which may be permanent. Notify your healthcare provider if you notice such changes. Though uncommon, severe allergic reactions can occur, characterized by rash, swelling, dizziness, or difficulty breathing. Immediate medical intervention is essential if these symptoms arise.

This guide covers many potential side effects, but if you notice anything unusual or concerning, contact your healthcare provider for further advice.

Certain medications can interact with this drug. These include orlistat, probenecid, ribavirin, and stavudine. Additionally, medications that might reduce bone marrow function, such as ganciclovir, dapsone, trimethoprim, and some chemotherapy drugs like doxorubicin and vincristine, can also interact.

Some drugs affect how your body processes zidovudine, potentially changing its effectiveness. Examples include methadone, rifampin, and seizure medications like phenytoin and valproic acid.

It's important not to take this medication alongside other drugs containing zidovudine. Always check your prescription labels to ensure they do not include zidovudine. If you have any concerns or questions, please consult your healthcare provider or pharmacist.