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Acetaminophen Safety and Warning Information:

Acetaminophen is commonly used to relieve pain and reduce fever, but it is important to use it safely to avoid serious health risks. Below are key safety considerations and warnings associated with its use:

• Liver Damage Risk: Consuming excessive amounts of acetaminophen can lead to severe liver damage, which may be life-threatening. The typical maximum daily dose for adults is 4,000 milligrams (4 grams), but this may be lower based on individual health conditions and healthcare provider recommendations. Children and individuals with liver issues should consult a healthcare provider for dosage guidance.

• Alcohol Interaction: Daily consumption of alcohol, especially in quantities of three or more drinks, can increase the risk of liver damage when combined with acetaminophen. It is advisable to avoid alcohol while taking this medication.

• Accidental Overdose: Many medications, both over-the-counter and prescription, contain acetaminophen. To prevent an accidental overdose, avoid taking multiple medications containing acetaminophen. Keep track of your total daily intake and consult a healthcare provider if unsure.

• Overdose Symptoms: In the event of an overdose, immediate medical attention is crucial, even if no symptoms are present. Symptoms can include nausea, vomiting, lack of appetite, excessive tiredness, stomach pain, yellowing of the skin or eyes, and dark urine. Contact a Poison Control Center at 1-800-222-1222 if an overdose is suspected.

• Allergic Reactions: Although rare, acetaminophen can cause severe skin reactions, such as rashes, blisters, or peeling. Discontinue use and seek medical help promptly if you experience any skin changes.

• Special Precautions: Individuals with pre-existing liver conditions should speak to their healthcare provider before using acetaminophen. Additionally, avoid using other medications containing acetaminophen to prevent increased risk of liver damage.

By adhering to these guidelines, the risk of adverse effects can be minimized, ensuring the safe use of acetaminophen. Always consult a healthcare provider if you have any concerns or questions regarding the use of this medication.

Common side effects:

• Mild nausea
• Headaches

Serious side effects:

• Severe allergic reactions
• Liver damage

Interactions with high risk of serious adverse effects and should be avoided:

• Imatinib
• Isoniazid
• Pixantrone
• Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acenocoumarol
• Carbamazepine
• Fosphenytoin
• Lixisenatide
• Phenytoin
• Warfarin
• Zidovudine

Interactions with low risk that usually do not require a change in therapy:

• Ketoconazole
• Levoketoconazole