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This section provides crucial safety information about the use of Adbry (tralokinumab). Please read carefully and consult with your healthcare provider if you have any questions or concerns.

• Risk of Serious Allergic Reactions: Using Adbry (tralokinumab) may result in severe allergic reactions, including potentially life-threatening anaphylaxis. If you experience symptoms such as throat constriction, difficulty breathing, dizziness, sweating, nausea, or swelling around the eyes, lips, or tongue, seek immediate medical attention.

• Eye-Related Side Effects: Adbry (tralokinumab) can lead to conditions like conjunctivitis (pink eye) or eye inflammation. Most individuals find these issues resolve over time. Should you notice any changes in vision, blurred vision, irritation, or itchy and watery eyes, consult your dermatologist or optometrist promptly.

• Infection Risk: The impact of Adbry (tralokinumab) on the immune system's ability to fight certain infections, such as parasitic infections, is not fully understood. It is important to inform your dermatologist of any existing infections before starting treatment. If you develop an infection while on Adbry (tralokinumab) and do not respond to antiparasitic treatment, discontinuation of the medication may be necessary until the infection clears.

• Vaccination Precaution: You should avoid live vaccines while taking Adbry (tralokinumab), as their safety is not established in this context. Live vaccines include those for chickenpox (Varivax) and measles, mumps, and rubella (MMR). Ensure your vaccinations are up to date before beginning treatment with Adbry (tralokinumab). Inform your healthcare provider or pharmacist about your current medication regimen prior to receiving any vaccines.

No specific contraindications have been identified for the use of Adbry (tralokinumab).

When considering Adbry (tralokinumab-ldrm) for the treatment of moderate-to-severe atopic dermatitis, it's important to be aware of potential interactions with other medications, vaccines, and certain health conditions.

Vaccinations: Adbry may affect your immune system's response to vaccines. Specifically, live vaccines—such as those for measles, mumps, rubella (MMR), and varicella (chickenpox)—should be avoided during treatment with Adbry, as they may increase the risk of infection. Before starting Adbry, ensure that all age-appropriate vaccinations are up to date. If you require vaccinations while on Adbry, consult your healthcare provider to determine the safest options.

Parasitic Infections: Adbry may influence the body's response to parasitic (helminth) infections. If you have a known helminth infection, it should be treated before initiating Adbry therapy. Should you develop a helminth infection during treatment that does not respond to standard anti-helminth therapy, discontinuation of Adbry may be necessary until the infection resolves.

Eye Conditions: Patients receiving Adbry have reported eye-related side effects, including conjunctivitis (pink eye) and keratitis (inflammation of the cornea). If you experience new or worsening eye symptoms, such as redness, itching, pain, or vision changes, inform your healthcare provider promptly.

Drug Interactions: Currently, no significant drug interactions have been identified between Adbry and other medications. However, it's essential to inform your healthcare provider about all prescription and over-the-counter medications, supplements, and herbal products you are using to ensure safe and effective treatment.

Always consult with your healthcare provider to discuss any potential interactions and to ensure that Adbry is appropriate for your specific health needs.