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The use of Evenity (romosozumab) comes with significant safety warnings and precautions. It is crucial to understand these in order to minimize potential risks and ensure safe use of the medication. Below are the key safety points to consider:

• Heart-related Risks: This medication has been associated with an increased risk of heart attack, stroke, or heart-related death, especially in postmenopausal women compared to those using alendronate. You should not use Evenity if you have had a heart attack or stroke in the past year. Discuss with your healthcare provider if you have other risk factors such as high blood pressure, high cholesterol, diabetes, obesity, or if you smoke. Be vigilant for heart attack symptoms like chest pain, shortness of breath, or dizziness, as well as stroke signs such as headache, vision changes, difficulty speaking, or muscle weakness. Seek immediate medical attention if these occur.

• Low Blood Calcium (Hypocalcemia): Patients may experience low calcium levels, particularly those with kidney damage or undergoing dialysis. Symptoms such as muscle pain, cramps, and numbness should be promptly addressed. Regular blood tests to monitor calcium levels are advised, and calcium and vitamin D supplements are recommended.

• Jawbone Health (Osteonecrosis): Instances of jawbone breakdown have been reported. Good oral hygiene is essential, and a dental examination is advised before starting treatment. Inform your healthcare provider about any dental procedures and ensure your dentist is aware you are taking Evenity. Symptoms to watch for include jaw pain, swelling, or exposed bone.

• Thigh Fractures: There is a risk of thigh fractures, especially in individuals over 65, those with low body weight, early menopause, or a history of fracture. Be alert to any unusual hip, thigh, or groin pain and report it to your healthcare provider.

Contraindications:

• Avoid using this medication if you have low calcium levels (hypocalcemia).

In the event of an overdose or if you experience any severe side effects, seek emergency medical assistance immediately. Always consult with your healthcare provider before starting or stopping the medication, especially if you have pre-existing health conditions or are taking other medications.

When considering the use of Evenity (romosozumab) for osteoporosis treatment, it's important to be aware of potential interactions and precautions:

Drug Interactions:

• Palopegteriparatide: Combining Evenity with palopegteriparatide may affect Calcium regulation in your body. This combination could lead to either high or low blood calcium levels. Symptoms of high calcium include nausea, vomiting, constipation, lethargy, and muscle weakness. Signs of low calcium include numbness or tingling around the mouth, muscle cramps, uncontrolled muscle movements, irritability, depression, irregular heartbeats, or confusion. If you're prescribed both medications, your doctor will monitor your calcium levels closely.

• Other Medications: Currently, there are no well-documented interactions between Evenity and other drugs. However, this doesn't guarantee that interactions don't exist. Always inform your healthcare provider about all medications, supplements, and herbs you're taking to ensure safety.

Health Conditions:

• Low Blood Calcium Levels (Hypocalcemia): Evenity can lower calcium levels in your blood. If you already have low calcium, your doctor will likely address this before starting Evenity. During treatment, you'll need to take calcium and Vitamin D supplements as prescribed to maintain healthy calcium levels.

• Severe Kidney Problems: Individuals with significant kidney issues or those on dialysis are at a higher risk of developing low blood calcium when using Evenity. Regular monitoring of calcium levels and appropriate supplementation are essential in these cases.

• Dental Health: Evenity has been associated with a rare condition called osteonecrosis of the jaw (ONJ), where the jawbone starts to die. This risk increases with invasive dental procedures like tooth extractions. It's advisable to have a dental check-up before starting Evenity and to inform your dentist about your treatment.

Alcohol Consumption:

While there's no direct interaction between Evenity and alcohol, excessive alcohol intake can weaken bones and increase the risk of fractures. Alcohol can also interfere with calcium absorption, potentially leading to lower calcium levels. It's best to discuss alcohol consumption with your doctor during Evenity treatment.

General Advice:

Always keep your healthcare provider informed about your complete medical history and any medications or supplements you're taking. This ensures that Evenity is both safe and effective for your osteoporosis treatment.