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When using adefovir dipivoxil, it is crucial to be aware of potential risks and necessary precautions to ensure safe treatment. Below are key safety warnings and guidelines for use:

• Worsening Hepatitis B: Stopping adefovir dipivoxil without your healthcare provider's guidance can lead to a severe return and worsening of hepatitis B, potentially escalating liver damage. If advised to discontinue the medication, maintain regular doctor and lab visits, especially in the initial three months, to monitor your liver health and hepatitis B status.

• Hepatitis B and HIV Co-infection: Adefovir dipivoxil is only approved for hepatitis B treatment, not HIV. If undiagnosed or untreated HIV is present, using this medication may result in drug resistance, complicating HIV treatment. Ensure regular HIV testing and consult your provider for a suitable treatment plan if co-infected with hepatitis B and HIV.

• Kidney Health: Long-term use of adefovir dipivoxil can harm kidney function, with increased risk if pre-existing kidney issues or concurrent nephrotoxic medications are present. Routine blood tests will be necessary to assess kidney health, and dosage adjustments may be required.

• Lactic Acidosis and Liver Concerns: Although rare, nucleoside analogs like adefovir dipivoxil can cause lactic acidosis and liver problems, particularly in women, individuals with obesity, or those on long-term treatment. Symptoms such as unusual tiredness, abdominal pain, and difficulty breathing warrant immediate medical attention.

By adhering to these guidelines and maintaining communication with your healthcare provider, you can effectively manage treatment with adefovir dipivoxil while minimizing potential risks.

Common side effects:

• Weakness or lack of energy
• Headaches
• Stomach pain
• Nausea
• Gas
• Diarrhea
• Upset stomach

Serious side effects:

• Lactic acidosis
• Liver problems
• Kidney issues
• Severe allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• tenofovir

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cidofovir