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When taking this medication, you might experience dizziness, diarrhea, headache, or difficulty sleeping. These are common side effects and usually mild, but if they persist or worsen, consult your healthcare provider. As your immune system strengthens during HIV treatment, it may reactivate previous infections or become overactive, potentially causing symptoms such as unexplained weight loss, fatigue, persistent muscle aches, or severe headaches. Seek medical attention immediately if these occur.

Serious side effects include mental or mood changes, kidney issues, and unusual thirst. If you notice these, contact your healthcare provider promptly. Rarely, this medication can lead to severe liver or blood problems like lactic acidosis. Symptoms include persistent nausea, abdominal pain, yellowing of the eyes or skin, or dark urine. Bone health is another consideration, as Tenofovir may cause bone loss. Discuss supplementation options with your healthcare provider and report any bone pain or fractures.

Rashes can occur and are typically not serious; however, if you develop a rash, it's important to seek medical advice to rule out a severe reaction. Though very rare, serious allergic reactions are possible, with symptoms like swelling, severe dizziness, or breathing difficulties requiring immediate medical attention. Always remain vigilant and report any unexpected effects to your healthcare provider.