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You may experience drowsiness, dizziness, increased saliva production, or changes in your sex drive or abilities while taking this medication. These are common side effects, and they usually resolve on their own. However, if they persist or worsen, it is advisable to consult your healthcare provider. To minimize the risk of dizziness or lightheadedness, try to rise slowly from sitting or lying down.

Serious side effects, although uncommon, require immediate attention. These include changes in mental state such as hallucinations or suicidal thoughts, difficulty speaking, loss of coordination, trouble walking, or memory issues. If you experience any of these, contact your healthcare provider right away.

Very serious side effects are rare but require urgent medical attention. These include yellowing of the eyes or skin, seizures, or symptoms of a severe allergic reaction like rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek medical help immediately.

This summary does not cover all possible side effects. If you notice any other unusual effects, reach out to your healthcare provider for guidance.

This medication may interact with certain products, including kava and Sodium Oxybate. Other medications can influence how alprazolam is eliminated from your body, potentially altering its effectiveness. These include adagrasib, azole antifungals (like Itraconazole, Ketoconazole), Cimetidine, some antidepressants (such as Fluoxetine, Fluvoxamine, Nefazodone), protease inhibitors (like indinavir), macrolide antibiotics (such as Erythromycin), rifamycins (like Rifabutin), St. John's wort, and seizure medications (such as Phenytoin), among others.

Taking this medication along with others that cause drowsiness or breathing issues can increase the risk of severe side effects, such as very slow or shallow breathing, and extreme drowsiness or dizziness. Inform your doctor or pharmacist if you are using other products like opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as Diazepam, Lorazepam, Zolpidem), muscle relaxants (like Carisoprodol, Cyclobenzaprine), or antihistamines (such as Cetirizine, diphenhydramine).

Be sure to check the labels of all your medications, including those for allergies or coughs and colds, as they may contain ingredients that cause drowsiness. Consult your pharmacist for advice on using these products safely. Additionally, smoking cigarettes decreases this medication's blood levels, so inform your doctor if you smoke or have recently quit smoking.