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This medication comes with several important safety warnings and usage guidelines. It is crucial to review these carefully and discuss any concerns with your healthcare provider.

• Seizure Risk: The use of Ampyra (dalfampridine) may lead to seizures, even in patients without a previous seizure history. These seizures can occur within days to weeks of starting the medication. Inform your healthcare provider if you have experienced seizures before or if you have conditions that increase your seizure risk. Immediate medical attention is necessary if a seizure occurs, and continued use of Ampyra (dalfampridine) may not be advisable. Increased risk factors include a seizure history and exceeding the prescribed dose of 10 mg twice daily.

• Kidney Function Concerns: Ampyra (dalfampridine) is eliminated from the body via the kidneys. Impaired kidney function can cause the medication to accumulate, increasing the likelihood of adverse effects such as seizures. The dose cannot be reduced to mitigate this risk for those with kidney issues. Therefore, individuals with existing kidney problems should not use Ampyra (dalfampridine).

• Severe Allergic Reactions: There is a risk of severe allergic reactions, including life-threatening conditions such as swelling of the mouth or face, shock, and anaphylaxis. If you experience symptoms like hives, a rash, red skin, swelling of the lips or tongue, or difficulty breathing, discontinue use immediately and seek emergency medical care.

Contraindications for Ampyra (dalfampridine) include:

• A history of seizures
• Moderate to severe kidney impairment

For your safety, consult your healthcare provider if any of these conditions apply to you before starting Ampyra (dalfampridine).

When taking this medication, some individuals may experience common side effects such as trouble sleeping (insomnia), dizziness, nausea, headache, urinary tract infections, and feelings of weakness or lack of energy. These effects are usually mild. However, if they persist or worsen, it is important to consult your healthcare provider for guidance.

Other side effects have also been reported and include back pain, balance problems, burning or prickling sensations in the hands and feet, runny nose or common cold symptoms, constipation, and upset stomach. While these effects can be bothersome, they are generally manageable. Should they become severe, contacting a healthcare professional is advisable.

There are rare but serious side effects that require immediate medical attention. These include mental or mood changes such as severe confusion or memory issues, seizures, and serious allergic reactions characterized by hives, rash, swelling, or difficulty breathing. If you experience any of these symptoms, seek urgent medical care.

While this information covers a range of possible side effects, it may not include all potential reactions. If you notice any unusual symptoms not listed, it is important to inform your healthcare provider promptly.

It is important to carefully review all prescription and compounded medication labels, as Dalfampridine, which is also referred to as 4-AP, 4-Aminopyridine, or fampridine, may be similar to other drugs you are taking. Combining these medications could increase the risk of seizures. If you are unsure about any of your medications, consult your doctor or pharmacist.

Ampyra (dalfampridine) can interact with certain drugs or supplements. It is essential to inform your healthcare provider about all medications and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products. While not exhaustive, some medications that might interact with Ampyra include Dolutegravir, Lacosamide, and Trilaciclib. Although using these drugs together is generally not recommended, it might be necessary in certain situations. If prescribed together, your doctor may need to adjust your dosage or the frequency of use.