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Trouble sleeping (insomnia), dizziness, nausea, and headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: frequent/burning/painful urination, back pain, pink/bloody urine, new/worsening balance problems. Get medical help right away if you have any very serious side effects, including: mental/mood changes (such as severe confusion, memory problems), seizure. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Check all prescription and compounded medicine labels carefully since this medication might be similar to other drugs you take. Dalfampridine is also known as 4-AP, 4-aminopyridine, and fampridine. Taking these drugs together could harm you (increased seizure risk). Ask your doctor or pharmacist if you are not sure about any medicines you take.