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Teriflunomide is not suitable for use during pregnancy due to the potential risk of causing serious harm, including birth defects or fetal death. Women who are able to conceive should undergo a pregnancy test with negative results prior to beginning treatment. Both men and women must use effective contraception methods, such as condoms or birth control pills, while taking teriflunomide and continue as advised by their healthcare provider to prevent pregnancy. After discontinuing teriflunomide, your doctor might recommend another medication to expedite its elimination from your body. If you suspect you are pregnant, become pregnant, or could potentially cause a pregnancy during treatment, contact your healthcare provider immediately.

Additionally, teriflunomide may rarely lead to severe, possibly life-threatening liver disease. To mitigate this risk, your doctor will conduct liver function tests before starting treatment and monthly for at least the first six months. Should you experience persistent nausea or vomiting, dark urine, loss of appetite, stomach or abdominal pain, or yellowing of the eyes or skin, inform your doctor promptly.

You may experience diarrhea, nausea, or sensations such as tingling, burning, numbness, or prickling in your skin. If these symptoms persist or worsen, it's important to inform your healthcare provider promptly. Temporary hair loss is another possible effect, but normal hair growth typically resumes after treatment ends. Many individuals taking this medication do not encounter severe side effects, as the benefits often outweigh the risks.

However, immediately report any serious side effects to your healthcare provider. These include easy bruising or bleeding, new or worsening shortness of breath, increased numbness or tingling in the hands and feet, flank pain, symptoms indicating high potassium levels like muscle weakness or irregular heartbeat, or unusual fatigue. This medication may also elevate blood pressure, so regular monitoring is advised, and any high readings should be communicated to your healthcare provider.

The drug may reduce your infection-fighting ability, increasing the risk of serious infections. Seek medical help promptly if you experience symptoms such as persistent sore throat, fever, chills, cough, or swollen lymph nodes. Teriflunomide can cause mild rashes, which are generally not serious, but it's crucial to seek medical attention for any rash, as it could signal a severe allergic reaction. Though rare, serious allergic reactions can occur, characterized by rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you experience any side effects not mentioned here, contact your healthcare provider for further advice.