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This medication carries several important safety considerations that patients and healthcare professionals should be aware of. Below are key points to keep in mind regarding potential risks, necessary precautions, and specific instructions for safe use.

• Allergic Reactions: This medication can trigger severe, potentially life-threatening allergic reactions. Such reactions may occur after the first dose or later in the treatment process, even years after starting. Symptoms to watch for include difficulty breathing, seizures, severe dizziness, rash, or itching/swelling, particularly of the face, tongue, or throat. If you experience any of these symptoms, immediately discontinue use and seek medical attention. Discuss with your doctor the distinction between post-injection reactions and serious allergic reactions.

• Injection Reactions: After injecting glatiramer (Copaxone), some individuals may experience reactions such as flushing, chest pain, a rapid heartbeat, anxiety, shortness of breath, throat tightness, or hives. These may occur seconds to minutes post-injection and can start months after beginning treatment. Usually, these reactions improve over time and do not require intervention.

• Chest Pain: Glatiramer (Copaxone) may cause chest pain either as an immediate reaction post-injection or as a side effect. This pain typically resolves on its own and is not an emergency unless accompanied by other symptoms like difficulty breathing, weakness, or light-headedness. In such cases, seek emergency medical help immediately, as these could indicate a heart attack.

• Fat Tissue Loss and Injection Site Necrosis: Repeated injections of glatiramer (Copaxone) can lead to permanent loss of fat tissue (lipoatrophy) at the injection sites. Rarely, it can also cause necrosis (cell death) of the skin at these sites. To minimize risk, rotate injection sites regularly.

• Liver Damage: Although rare, serious liver complications may arise, potentially leading to liver failure or death. Seek immediate medical help if you notice symptoms such as abdominal swelling, jaundice, changes in stool, coughing or vomiting blood, confusion, slurred speech, mood changes, or personality shifts. Discontinuing glatiramer (Copaxone) might be necessary to prevent further liver damage.

• Contraindications: Do not use this medication if you have an allergy to mannitol, as it may pose serious health risks.

Always consult your healthcare provider with any concerns or if you experience any adverse effects. They can provide guidance tailored to your specific health needs.

Common side effects:

• Warmth at the injection site
• Pain at the injection site
• Itching at the injection site
• Swelling at the injection site
• Nausea
• General body pain
• Weakness
• Rash
• Anxiety
• Trouble breathing

Less common but important to monitor:

• Vomiting
• Pounding heart
• Fever
• Runny nose
• Cough
• Cramps
• Diarrhea

Serious side effects:

• Severe injection site reactions like necrosis
• Throat tightness
• Difficulty breathing
• Persistent nausea
• Yellowing of the skin or eyes
• Swelling of the stomach
• Confusion