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The following safety information outlines important warnings associated with the use of diflorasone (Apexicon E). It is crucial to understand these potential risks and consult with your healthcare provider if you have any questions or concerns.

• Hormonal Imbalance: Excessive absorption of diflorasone through the skin may lead to symptoms of hormonal imbalance, such as easy bruising or elevated blood sugar levels. This risk is heightened when the medication is applied over large areas, used for prolonged periods, covered with bandages, or in younger patients.

• Skin Reactions: Users may experience skin reactions, including burning, itching, dryness, inflammation of hair follicles, excessive hair growth, and changes in skin color. It is important to inform your healthcare provider if you encounter any of these side effects.

• Increased Risk of Skin Infections: Diflorasone can reduce the skin's ability to combat infections. It is vital to treat existing skin infections with appropriate antifungal or antibacterial medications while using diflorasone. Prolonged use increases the likelihood of infection. Discontinue use and consult your healthcare provider if you observe redness, pain, swelling, or pus at the application site.

• Eye Health Concerns: Use of topical steroids, including diflorasone, may increase the risk of eye conditions such as cataracts and glaucoma. Although more common with direct eye application, similar effects have been observed in individuals using diflorasone for skin conditions. Seek medical attention if you experience any changes in vision.

Please follow these guidelines to ensure safe and effective use of diflorasone (Apexicon E).

ApexiCon E, containing the active ingredient diflorasone diacetate, is a potent topical corticosteroid used to alleviate inflammation and itching associated with various skin conditions. While it is applied externally and generally has minimal systemic absorption, certain interactions and precautions should be considered to ensure safe and effective use.

Drug Interactions:

There are 47 known moderate drug interactions with ApexiCon E. It's important to inform your healthcare provider about all medications, supplements, and over-the-counter products you are currently using to avoid potential interactions.

Disease Interactions:

ApexiCon E may interact with certain medical conditions, including:

• Diabetes: Topical corticosteroids can elevate blood sugar levels, potentially complicating diabetes management.

• Infections: Using corticosteroids on infected skin can worsen the infection. Ensure the treated area is free from infections before application.

• Ocular Conditions: Avoid contact with the eyes, as corticosteroids can increase the risk of cataracts and glaucoma. Report any visual disturbances to your healthcare provider promptly.

General Precautions:

• Application Guidelines: Apply a thin layer to the affected area as directed by your healthcare provider. Do not cover the treated area with bandages or dressings unless instructed, as this can increase absorption and the risk of side effects.

• Pediatric Use: Children may absorb larger amounts of topical corticosteroids, leading to potential systemic side effects. Use in pediatric patients should be under strict medical supervision.

• Long-Term Use: Prolonged use can lead to skin thinning and other side effects. Use the medication for the duration prescribed and consult your healthcare provider if symptoms persist.

Always consult with your healthcare provider before starting or stopping any medication, and discuss any existing health conditions to ensure ApexiCon E is appropriate for your use.