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This medication comes with several important safety considerations that you should be aware of before use. Please read the following warnings carefully and consult your healthcare provider if you have any questions or concerns.

• Adrenal Gland Function Reduction: Prolonged use of topical triamcinolone over large areas of skin can occasionally lead to a condition known as adrenal suppression. This occurs when the body's production of steroid hormones decreases, potentially resulting in dependency on the medication. Discontinuing the medication abruptly can cause withdrawal symptoms such as fever, joint or muscle pain, and fatigue. In children, symptoms may include growth delays, weight gain, and headaches. To minimize the risk of adrenal suppression, your healthcare provider will prescribe the lowest effective dose for the shortest duration. Always consult your healthcare provider before stopping triamcinolone. Risks include high-potency topical steroids, long-term use, excessive application, using bandages over treated areas, and use in young children.

• Risk of Skin Infection: Extended use of triamcinolone may increase the likelihood of skin infections, including fungal and bacterial types. Avoid using triamcinolone on infected skin, as it can exacerbate the condition. Inform your healthcare team if you experience redness, swelling, pain, pus, or if symptoms persist after several days of treatment, as these may indicate a new infection.

• Skin Reactions: Using triamcinolone beyond the prescribed period can elevate the risk of adverse skin reactions such as thinning skin, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rash. To prevent these severe reactions, your healthcare provider will recommend the lowest dose necessary to manage your symptoms for the shortest time frame. Contact your healthcare provider if you observe any new or worsening skin issues. Risks include excessive and inappropriate use of triamcinolone and applying large amounts.

Always follow your healthcare team's guidance regarding the use of this medication to ensure safe and effective treatment.

Common side effects:

• burning
• itching
• skin irritation
• dryness

Less common but important to monitor:

• inflamed hair follicles
• excessive hair growth
• acne-like bumps
• changes in skin color
• rash
• skin thinning
• stretch marks
• heat rash

Serious side effects:

• withdrawal symptoms
• long-term fatigue
• muscle weakness
• poor appetite
• weight loss
• stomach pain
• unusual tiredness
• headache
• swelling of ankles or feet
• increased thirst or urination
• vision problems
• serious allergic reaction
• severe dizziness
• trouble breathing

When using Triamcinolone Acetonide in Absorbase®, it's important to be aware of potential interactions with other medications and substances. While this topical corticosteroid is primarily applied to the skin, some absorption into the bloodstream can occur, especially with prolonged use, application over large areas, or when used with occlusive dressings. This absorption may lead to interactions similar to those seen with systemic corticosteroids.

Medications That May Interact with Triamcinolone Acetonide in Absorbase®:

• CYP3A4 Inhibitors: Drugs that inhibit the CYP3A4 enzyme, such as Ketoconazole, Ritonavir, and Clarithromycin, can decrease the metabolism of corticosteroids like triamcinolone. This can lead to increased corticosteroid levels in the body, raising the risk of side effects.

• CYP3A4 Inducers: Conversely, medications that induce CYP3A4, including barbiturates, Phenytoin, and Rifampin, may enhance the metabolism of corticosteroids, potentially reducing their effectiveness.

• Diuretics: Concurrent use with diuretics like Furosemide or thiazide diuretics can increase the risk of hypokalemia (low potassium levels).

• Anticoagulants: Combining corticosteroids with blood thinners such as Warfarin may affect blood clotting. It's essential to monitor coagulation indices to maintain the desired anticoagulant effect.

• Antidiabetic Agents: Corticosteroids can elevate blood glucose levels, potentially diminishing the effectiveness of antidiabetic medications. Blood sugar levels should be closely monitored, and adjustments to diabetes medications may be necessary.

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Using NSAIDs alongside corticosteroids can increase the risk of gastrointestinal side effects, including ulcers and bleeding.

Other Considerations:

• Vaccines: Live vaccines should generally be avoided during corticosteroid therapy, as the immune response may be diminished, reducing vaccine efficacy.

• Estrogens: Estrogen-containing medications may decrease the metabolism of corticosteroids, potentially enhancing their effects and side effects.

Recommendations:

• Consult Your Healthcare Provider: Before starting Triamcinolone Acetonide in Absorbase®, inform your doctor about all medications, supplements, and over-the-counter products you are currently using.

• Monitor for Side Effects: Be vigilant for signs of increased corticosteroid effects, such as weight gain, fluid retention, elevated blood pressure, or blood sugar changes.

• Regular Check-Ups: If using this medication over large areas or for extended periods, regular medical evaluations may be necessary to monitor for systemic absorption and potential side effects.

By being aware of these potential interactions and working closely with your healthcare provider, you can use Triamcinolone Acetonide in Absorbase® safely and effectively.