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The medication Teriflunomide, also known as Aubagio, comes with several important safety warnings and precautions that must be considered before and during its use. Below are the key points to be aware of:

• Pregnancy Risks: Teriflunomide may cause severe harm to an unborn child, including birth defects and potentially fatal outcomes. Women who can conceive must have a negative pregnancy test before starting the medication and must use effective contraception during treatment. If pregnancy occurs or is suspected, contact your healthcare provider immediately. After discontinuing the drug, a procedure may be necessary to expedite its removal from the body.

• Liver Safety: The use of Teriflunomide can lead to serious liver damage, which in severe cases may require a liver transplant. Those with pre-existing liver conditions or using other liver-affecting drugs are at higher risk. Regular liver function tests will be conducted to monitor your condition, and treatment may be stopped if liver damage symptoms, such as persistent nausea, loss of appetite, dark urine, or jaundice, are observed.

• Infection Risk: This medication can weaken the immune system, increasing susceptibility to serious infections. Individuals with ongoing or recurrent infections, or those using immunosuppressive therapies, should discuss their risks with a healthcare provider.

• Vaccination Guidance: Ensure that all routine vaccinations are updated before starting Teriflunomide. The medication may reduce vaccine effectiveness, and live vaccines should be avoided due to potential risks.

• Skin and Allergic Reactions: Rare but severe skin conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may occur. Seek immediate medical attention if you develop painful skin sores or blisters. Severe allergic reactions, including anaphylaxis, are also possible. Emergency treatment should be sought if symptoms such as facial swelling or throat closure occur.

• Nerve and Lung Issues: Some users have experienced nerve damage leading to numbness or tingling, which may persist after stopping the medication. If such symptoms arise, inform your provider. There’s also a rare risk of interstitial lung disease, presenting with cough or difficulty breathing, which requires prompt medical attention.

• Contraindications: Teriflunomide should not be used by individuals with severe liver issues, those who are pregnant or not using contraception (if applicable), or those allergic to leflunomide or Teriflunomide. Concurrent use with leflunomide is also contraindicated.

In the event of an overdose, seek immediate medical assistance. Always consult your healthcare provider with any concerns or questions regarding this medication.

When taking this medication, it's common to experience some mild side effects, including diarrhea, nausea, headache, and temporary hair loss. These symptoms are generally not severe, and hair growth typically resumes after treatment. Abnormal liver tests and a tingling sensation, often described as "pins and needles" in the arms and legs, may also occur. Joint pain and high blood pressure are other possible effects. If any of these persist or worsen, consult your healthcare provider.

More serious side effects are rare, but they require immediate medical attention. These include symptoms of liver problems such as nausea, vomiting, stomach pain, swelling, yellowing of the skin or eyes, clay-colored stools, and confusion. Infections may present as fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, or chills. Serious allergic reactions might involve a rash, hives, painful blisters, skin reddening, peeling, sore throat, fever, fatigue, and swollen lymph nodes.

It's important to monitor for these symptoms and seek urgent care if they occur. Additionally, this medication may lower your ability to fight infections, making it crucial to be vigilant about signs of infection like a persistent sore throat, fever, or cough. While a mild rash may develop, it's vital to get medical help if you suspect a severe allergic reaction, as these are rare but serious. Always communicate any new or worsening symptoms to your healthcare provider to ensure your safety while using this medication.