Leflunomide Coupons & Discount Card - Compare Prices Near You
generic Arava
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10MG, Leflunomide (30 Tablets)
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CVS
$20.70
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Rite Aid
$13.54
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Albertsons
$23.36
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Walgreens
$117.31
COUPON PRICELeflunomide savings card
Show this card to your pharmacistCVS
$20.70
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GRP
019876
LH2E8D4942
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More prescriptions for rheumatoid arthritis
More prescriptions for rheumatoid arthritis
Leflunomide dosage forms
| Dosage | Quantity | Price from | Per unit |
|---|---|---|---|
| 10MG | 30 Tablets | $12.24 | $0.41 |
| 20MG | 30 Tablets | $12.4 | $0.41 |
Leflunomide Warnings
The use of Leflunomide (Arava) is accompanied by important safety considerations and warnings. Patients and healthcare providers should pay careful attention to the following information to ensure safe and effective use:
Pregnancy Risks: Leflunomide is contraindicated during pregnancy due to the risk of severe harm or potentially fatal effects to the unborn baby. Women of childbearing potential must undergo a negative pregnancy test before initiating treatment and use reliable contraception during and after treatment until the drug is effectively cleared from the body. If pregnancy is suspected, immediate medical consultation is required.
Liver Concerns: This medication can cause serious liver damage, sometimes necessitating a liver transplant. Patients with existing liver conditions, such as hepatitis B or C, should avoid leflunomide. Regular liver function tests are recommended. Symptoms that require urgent medical attention include persistent nausea, vomiting, dark urine, light-colored stools, abdominal pain, or yellowing of the skin or eyes.
Infection Risks: Leflunomide may impair the immune system, increasing the risk of serious infections. Prior to starting treatment, screening for infections like tuberculosis is advised. Patients with active or recurrent infections, or those on immunosuppressive drugs, should discuss potential risks with their healthcare provider.
Blood Cell Counts: The medication can reduce blood cell counts, leading to conditions like thrombocytopenia or anemia, and heightening infection risks. Monitoring blood counts is recommended to prevent complications.
Allergic Reactions: Severe allergic responses, including anaphylaxis, may occur. Rarely, drug reaction with eosinophilia and systemic symptoms (DRESS) can develop. Immediate medical care is required for signs of severe allergic reactions.
Nerve Pain: Leflunomide can cause nerve pain, which may persist post-treatment. Patients experiencing pain, numbness, or tingling should contact their healthcare provider to discuss discontinuation and potential detoxification steps.
Lung Issues: Interstitial lung disease, although rare, can develop at any point during treatment and may be life-threatening. Symptoms like cough or breathing difficulties warrant prompt medical evaluation.
Hypertension: Leflunomide may elevate blood pressure. Regular monitoring is necessary, and any significant changes should be reported to the healthcare team.
Drug Elimination: The medication may remain in the body for up to two years after cessation. For those planning pregnancy or experiencing adverse effects, methods like cholestyramine or activated charcoal may be used under medical supervision to expedite drug removal.
Contraindications: Do not use Leflunomide if you have severe liver problems, are currently pregnant, are not using birth control (if capable of pregnancy), are allergic to leflunomide or teriflunomide, or are taking teriflunomide for multiple sclerosis.
In case of overdose, seek immediate medical attention. Always consult with your healthcare provider for personalized advice and before making any changes to your medication regimen.
Leflunomide Side Effects
Common side effects:
- diarrhea
- headache
- nausea
- mild rash
Less common but important to monitor:
- abnormal liver labs
- hair thinning or loss
- elevated blood pressure
- dizziness
- weakness
- back pain
- joint stiffness
- stomach discomfort
- vomiting
- bronchitis
- runny nose
- mouth sores
- itchy skin
Serious side effects:
- significant liver issues
- serious infections
- severe allergic reactions
Leflunomide Interactions
Interactions with high risk of serious adverse effects and should be avoided:
Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:
- Cholestyramine
- Warfarin
- Methotrexate
- Acyclovir
- Atorvastatin
- Methotrexate
- Adenovirus Vaccine
- Baricitinib
- Bosentan
- Cefaclor
- Ciprofloxacin
- Dabrafenib
- Dasabuvir
- Dengue Tetravalent Vaccine, Live
- Elagolix
- Enzalutamide
- Furosemide
- Glyburide
- Grazoprevir
- Influenza Virus Vaccine, Live
- Irinotecan
- Letermovir
- Measles Virus Vaccine, Live
- Montelukast
- Mumps Virus Vaccine, Live
- Paclitaxel
- Pexidartinib
- Pitavastatin
- Poliovirus Vaccine, Live
- Repaglinide
- Revefenacin
- Rosuvastatin
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Simvastatin
- Smallpox Vaccine
- Sulfasalazine
- Tenofovir Alafenamide
- Topotecan
- Valacyclovir
- Varicella Virus Vaccine, Live
- Yellow Fever Vaccine
- Zoster Vaccine, Live
Interactions with low risk that usually do not require a change in therapy:
- Ketorolac
- Tovorafenib
- Vorasidenib
Which is safer, methotrexate or leflunomide?
The safety of methotrexate versus leflunomide can depend on the individual patient's health condition, medical history, and specific circumstances. Both medications have potential side effects and risks. Methotrexate is often used as a first-line treatment for rheumatoid arthritis and is generally well-tolerated, but it can cause liver toxicity, bone marrow suppression, and lung issues. Leflunomide can also be effective but may cause liver damage, hypertension, and gastrointestinal issues. It is important for a healthcare provider to evaluate the risks and benefits of each medication for the individual patient to determine which is safer for them. Regular monitoring and follow-up are essential when using either medication.
Which is safer methotrexate or leflunomide?
The safety of methotrexate versus leflunomide can vary depending on the individual patient's health condition, medical history, and specific circumstances. Both medications have potential side effects and risks. Methotrexate is often associated with liver toxicity, bone marrow suppression, and lung issues, while leflunomide can cause liver damage, hypertension, and gastrointestinal problems. It is essential for a healthcare provider to evaluate the patient's overall health and treatment goals to determine which medication is safer for them. Regular monitoring and follow-up are crucial when using either medication.
What is the safest rheumatoid arthritis drug?
The safety of rheumatoid arthritis medications can vary depending on the individual's health profile, disease severity, and response to treatment. Generally, nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are considered relatively safe for short-term use to manage symptoms. However, for long-term management, disease-modifying antirheumatic drugs (DMARDs) like methotrexate are commonly used and have a well-established safety profile when monitored appropriately. Biologic DMARDs are also effective but may carry a higher risk of infections. It is essential for patients to discuss with their healthcare provider to determine the safest and most effective treatment plan tailored to their specific needs.
How toxic is leflunomide?
Leflunomide can be toxic, particularly to the liver. It may cause liver damage, and regular monitoring of liver function tests is recommended for patients taking this medication. Other potential toxic effects include bone marrow suppression, which can lead to decreased blood cell counts, and gastrointestinal issues. It is important for patients to be closely monitored by their healthcare provider while on leflunomide to manage and mitigate these risks.
Should I take leflunomide or methotrexate?
The decision between leflunomide and methotrexate should be made in consultation with a healthcare provider, as it depends on the individual's specific medical condition, history, and response to treatment. Both medications are used to treat rheumatoid arthritis and have different side effect profiles and mechanisms of action. A healthcare provider can assess the benefits and risks of each medication based on the patient's unique situation.