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The safety information provided below outlines important considerations when using Avonex (interferon beta-1a). It is crucial to review these details and discuss any concerns with your healthcare provider.

• Mental Health Risks: Avonex (interferon beta-1a) may impact mental health, potentially causing depression, aggressive behavior, or, in severe instances, thoughts of self-harm or harm to others. Individuals with a history of violent behavior or certain mental health conditions should use this medication with caution. Notify your healthcare provider if you experience mood changes while taking Avonex, as these symptoms typically subside after discontinuation of the medication.

• Liver Damage: This medication can lead to liver damage, sometimes resulting in serious liver issues. Your healthcare provider will closely monitor your liver function through blood tests and may discontinue the medication if liver function tests become elevated. Be alert to symptoms such as severe stomach pain, pale stools, dark urine, or jaundice (yellowing of the skin or eyes) and report them to your provider immediately. Individuals who consume alcohol heavily or take other liver-impacting medications are at higher risk.

• Heart Problems: Avonex (interferon beta-1a) has been associated with heart issues, including congestive heart failure. If you have a history of heart conditions, inform your healthcare provider, and ensure your cardiologist is aware you are taking this medication. Your heart health may need to be monitored more closely.

• Lower Blood Cell Counts: There is a risk of reduced blood cell counts, especially for those taking other medications that similarly affect blood cell levels. Discuss any existing medications with your healthcare provider.

• Seizure Risk: Although rare, seizures have been reported with the use of Avonex (interferon beta-1a). If you have a history of seizures, disclose this information to your healthcare provider before starting treatment.

In case of an overdose, seek emergency medical attention immediately. Always ensure open communication with your healthcare provider about your medical history and any other medications you are taking to minimize risks and manage your health effectively while using Avonex (interferon beta-1a).

When taking this medication, some common side effects may occur, usually mild in nature. These include headaches, flu-like symptoms such as fever, chills, muscle aches, and tiredness. These symptoms are often temporary, improving after a few months of use. To manage these, consider taking the medication at bedtime and using pain relievers like acetaminophen or ibuprofen. Other common side effects include dizziness, depression, urinary tract infections, and injection site reactions such as pain, swelling, or redness. If these symptoms persist or worsen, consult your healthcare provider.

While the majority of users experience only mild effects, there are more serious side effects that warrant attention. Contact your healthcare provider if you notice mental or mood changes, such as new or worsening depression, thoughts of suicide, or psychosis. Additionally, be alert for signs of heart failure, kidney or liver problems, or unusual bleeding. Symptoms like shortness of breath, swelling, changes in urine output, severe abdominal pain, or yellowing of the skin require prompt medical evaluation.

Rare but severe side effects, such as seizures, chest pain, and significant allergic reactions, necessitate immediate medical attention. Signs of a serious allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. Furthermore, this medication may lower your immune response, increasing susceptibility to infections. Report any persistent sore throat, fever, or cough to your healthcare provider promptly.

Overall, while side effects are possible, many users do not experience serious issues. However, it is important to remain vigilant and seek medical advice if you encounter any concerning symptoms.