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The following safety information is essential for understanding the potential risks and necessary precautions when using this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Concurrent Use of Acne Treatments: It is advised not to use other acne treatments simultaneously with Benzamycin (erythromycin/benzoyl peroxide) to avoid excessive skin irritation and adverse effects. Initial mild skin irritation may occur with Benzamycin, but if irritation intensifies, consult your healthcare provider.

• Risk of Severe Diarrhea: Prolonged use of Benzamycin (erythromycin/benzoyl peroxide) may increase the risk of a gut infection caused by the bacteria C. difficile, which can lead to severe diarrhea. This risk persists throughout the treatment and for several months post-treatment. If you experience diarrhea or notice blood in your stool, seek medical advice immediately, as these symptoms may be medication-related.

When using this medication, some individuals may encounter common side effects, such as mild dryness and peeling of the skin's top layer. It's typical to experience skin irritation, itching, burning, or redness, particularly at the start of treatment as your skin adjusts. Additionally, dry skin and hives occur in a small percentage of users. These effects are generally mild, but if they persist or worsen, it is advisable to consult your healthcare provider.

On occasion, users might experience other side effects including swelling of the face, eyes, and nose, along with eye irritation. If you notice any of these symptoms, even if they are not severe, reaching out to your healthcare provider can be helpful for guidance and reassurance.

While serious side effects are rare, prolonged or repeated use of this medication might lead to other skin infections, such as fungal infections. Unusual skin symptoms or lack of improvement should prompt a discussion with your healthcare provider. A very serious allergic reaction is also rare, but you should seek immediate medical attention if you experience rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Always stay alert to any other effects not mentioned here and consult your healthcare provider for further advice.

When using Benzamycin (Erythromycin/Benzoyl Peroxide), it's important to be aware of potential interactions with other medications and products. Skin products such as Dapsone, cosmetics, medicated soaps, after-shave lotions, and any containing alcohol can increase skin irritation, dryness, and peeling. Consult your doctor or pharmacist to determine which products to use or avoid and how to minimize skin irritation.

Additionally, Benzamycin may have significant interactions with a wide range of medications. Some drugs should not be used with Benzamycin, including Astemizole, Bepridil, and Cisapride, among others. Your doctor might choose not to prescribe these together or adjust your current medication regimen.

There are other medications that are usually not recommended for use with Benzamycin, but exceptions can be made. If prescribed together, your doctor may alter the dosage or frequency of either medication. This list includes medications like Abametapir, Acalabrutinib, and many others.

Lastly, using Benzamycin with certain drugs might increase the risk of side effects, but the combination may still be necessary for treatment. In such cases, dose adjustments may be required. This includes medications like Anisindione, Apixaban, and others. Always inform your healthcare provider about all medicines and supplements you are taking to avoid adverse interactions.